Poxvirus Interactions with the Host Ubiquitin System.
Poxvirus Interactions with the Host Ubiquitin System.
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DOI：
10.3390/pathogens10081034
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发表时间：
2021-08-16
期刊：
影响因子：
--
通讯作者：
Maluquer de Motes C
中科院分区：
文献类型：
--
作者：
Lant S;Maluquer de Motes C
泛素系统已成为许多(如果不是全部)细胞功能的主要调节者。泛素系统拥有大量的连接和连接酶，在操纵蛋白质功能方面具有独特的机制来提供选择性和特异性。作为细胞内的寄生虫，病毒已经进化到调节细胞环境，以促进复制和颠覆抗病毒反应。痘病毒是一个编码能力很大的dsDNA病毒大家族，用于合成复制和形态形成以及抑制宿主反应所需的蛋白质和酶。本文综述了痘病毒的功能如何依赖于细胞泛素系统，以及痘病毒如何利用这一系统来发挥自身的优势，促进脱壳和基因组的释放和复制，或者重新连接泛素连接酶来下调关键的抗病毒因子。虽然我们对痘病毒和宿主泛素系统之间复杂的相互作用仍有很多了解，但我们的知识已经揭示了关键的病毒过程和重要的限制因素，为抗病毒治疗开辟了新的途径，并为痘病毒和其他病毒家族的生物学提供了基本的见解。
The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in manipulating protein function. As intracellular parasites viruses have evolved to modulate the cellular environment to facilitate replication and subvert antiviral responses. Poxviruses are a large family of dsDNA viruses with large coding capacity that is used to synthetise proteins and enzymes needed for replication and morphogenesis as well as suppression of host responses. This review summarises our current knowledge on how poxvirus functions rely on the cellular ubiquitin system, and how poxviruses exploit this system to their own advantage, either facilitating uncoating and genome release and replication or rewiring ubiquitin ligases to downregulate critical antiviral factors. Whilst much remains to be known about the intricate interactions established between poxviruses and the host ubiquitin system, our knowledge has revealed crucial viral processes and important restriction factors that open novel avenues for antiviral treatment and provide fundamental insights on the biology of poxviruses and other virus families.
影响因子：
3.7
作者：
Mathew A;O'Bryan J;Marshall W;Kotwal GJ;Terajima M;Green S;Rothman AL;Ennis FA
通讯作者：
Ennis FA