The mannose-binding lectin: a prototypic pattern recognition molecule.
The mannose-binding lectin: a prototypic pattern recognition molecule.
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DOI：
10.1016/j.coi.2005.11.014
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发表时间：
2006-03
影响因子：
7
通讯作者：
Ezekowitz RA
中科院分区：
文献类型：
--
作者：
Takahashi K;Ip WE;Michelow IC;Ezekowitz RA
先天免疫系统由复杂的识别和效应分子网络组成，它们共同作用，在宿主暴露于感染性挑战的最初几分钟或几小时内保护宿主。甘露糖结合凝集素 (MBL) 是一种进化保守的循环宿主防御蛋白，可作为针对多种感染因子的广谱识别分子。靶标结合触发补体激活的 MBL 途径。从概念上讲，MBL 可以被视为“前抗体”，因为它在哺乳动物的滞后期中发挥着作用，该滞后期是针对传染源产生抗体反应所需的。此外，在缺乏激活原始补体系统的适应性免疫的动物中存在MBL样同源物，并且在这种情况下，这些MBL样分子在高等动物中发挥与抗体类似的作用。这些分子可能被认为是抗体的功能前身。最近的研究还表明，MBL 可以识别改变的自身抗原，因此 MBL 的作用超出了一线宿主防御中的传统作用，因为它似乎发挥了炎症调节剂的作用。
The innate immune system is comprised of a sophisticated network of recognition and effector molecules that act together to protect the host in the first minutes or hours of exposure to an infectious challenge. The mannose-binding lectin (MBL) is an evolutionary conserved circulating host defense protein that acts as a broad-spectrum recognition molecule against a wide variety of infectious agents. Target binding triggers the MBL pathway of complement activation. MBL can be considered conceptually as an ‘ante-antibody’ because it has a role in mammals during the lag period that is required to develop an antibody response against infectious agents. Additionally, there are MBL-like homologues in animals that lack adaptive immunity that activate a primitive complement system, and under these circumstances these MBL-like molecules play an analogous role to antibodies in higher animals. These molecules might be considered to be functional antecedents of antibodies. Recent work also indicates that MBL recognizes altered self-antigens, and as such MBL has a role that extends beyond a traditional role in first line host defense as it appears to play a role as a modulator of inflammation.
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影响因子：
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