Host tissue response in chronic periodontal disease. 1. The normal periodontium and clinical manifestations of dental and periodontal disease in the marmoset.
Host tissue response in chronic periodontal disease. 1. The normal periodontium and clinical manifestations of dental and periodontal disease in the marmoset.
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慢性牙周病的宿主组织反应。
DOI：
10.1111/j.1600-0765.1972.tb00638.x
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发表时间：
1972
影响因子：
3.5
通讯作者：
R. Page
中科院分区：
文献类型：
--
作者：
Ammons Wf;L. Schectman;R. Page
研究了群养绒猴炎症性牙周病的临床表现。该疾病的临床特征是急性炎症反应，包括红肿、渗出和自发性出血。组织病理学上，观察到的细胞反应由中性粒细胞和单核细胞组成，其中一些可以明确地确定为巨噬细胞。淋巴细胞-浆细胞浸润是人类疾病的一个主要特征，但在狨猴身上却不是一个突出的特征。事实上，即使用电子显微镜也只发现了少量的这些细胞。因此，狨猴的宿主组织反应似乎与在人身上看到的有很大不同，因此必须保留使用狨猴作为人类形式疾病的模型。观察到慢性牙周病的重要临床和组织病理学表现可以在没有广泛淋巴细胞-浆细胞浸润的情况下发生在这种动物身上，这表明，与目前的概念相反，这些细胞在局部部位的活性可能不是牙周病的诱导和进展所必需的。
Manifestations of inflammatory periodontal disease in a. colony-maintained marmoset were studied. The disease was characterized clinically by an acute inflammatory response including redness, edema, exudation and spontaneous hemorrhage. Histopathologically, the cellular response observed was comprised of neutrophils and mononuclear cells, some of which could be definitively identified as macrophages. The lymphocyte-plasma cell infiltrate which comprises a major feature of the disease in man was not a prominent feature in the marmoset. Indeed, only insignificant numbers of these cells were found even with electron microscopy. Thus, the host tissue response in the marmoset appears to differ significantly from that seen in man, and reservations must be exercised in the use of the marmoset as a model of the human form of the disease. The observation that the important clinical and histopathologic manifestations of chronic periodontal disease can occur in this animal without the presence of an extensive lymphocyte-plasma cell infiltrate suggest that, contrary to current concepts, the activity of these cells at the local site may not be essential to the induction and progress of periodontal disease.