Neuromesodermal progenitors and the making of the spinal cord.
Neuromesodermal progenitors and the making of the spinal cord.
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DOI：
10.1242/dev.119768
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发表时间：
2015-09-01
期刊：
影响因子：
--
通讯作者：
Storey KG
中科院分区：
文献类型：
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作者：
Henrique D;Abranches E;Verrier L;Storey KG
神经中胚层祖细胞（NMPs）有助于延长脊髓和相邻的近轴中胚层。据推测，这些细胞的出现是由于前神经板的图案化。然而，随着体内指定NMps的分子机制的发现，以及体外从小鼠和人类多能干细胞产生这些双能细胞的方案的建立，新出现的数据表明，这种观点需要修改。本文就核基质蛋白的特性、调控、体外衍生和体内诱导等方面的研究进展作一综述。我们建议，这些细胞出现在原始条纹相关的上胚层通过一种机制，这是从建立神经命运的前上胚层分离。因此，我们认为存在两种不同的途径，使中枢神经系统祖细胞。
Neuromesodermal progenitors (NMps) contribute to both the elongating spinal cord and the adjacent paraxial mesoderm. It has been assumed that these cells arise as a result of patterning of the anterior neural plate. However, as the molecular mechanisms that specify NMps in vivo are uncovered, and as protocols for generating these bipotent cells from mouse and human pluripotent stem cells in vitro are established, the emerging data suggest that this view needs to be revised. Here, we review the characteristics, regulation, in vitro derivation and in vivo induction of NMps. We propose that these cells arise within primitive streak-associated epiblast via a mechanism that is separable from that which establishes neural fate in the anterior epiblast. We thus argue for the existence of two distinct routes for making central nervous system progenitors.