Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
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DOI：
10.1038/jhg.2012.129
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发表时间：
2013-01-01
影响因子：
3.5
通讯作者：
Bharadwaj, Dwaipayan
中科院分区：
文献类型：
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作者：
Dwivedi, Om Prakash;Tabassum, Rubina;Bharadwaj, Dwaipayan
黑皮质素 4 受体 (MC4R) 基因附近的常见变异已被证明与肥胖相关，但在不同年龄组中具有不同的影响。在印度人中，研究表明这些变异与成人肥胖有关，但其与儿童的关联尚未得到证实。我们评估了 MC4R 附近的 rs17782313 和 rs12970134 与印度人肥胖及相关特征的关联，其中包括 1362 名儿童和 4077 名成人（包括 2049 名糖尿病受试者和 2028 名非糖尿病成人受试者）。 rs17782313 和 rs12970134 两种变体均与儿童肥胖指标（体重、体重指数和腰围）密切相关（P 范围 7.6 x 10(-5)-3.8 x 10(-12)），与非糖尿病成人名义相关（P 范围 0.05-0.003）。儿童肥胖指标的效应大小（β 范围 0.22-0.26 Z 值）与成人（β 范围 0.06-0.08）相比高出 3 倍。两种变体的次要等位基因均与成人 2 型糖尿病风险存在边缘关联（P 范围 0.08-0.04）。对超过 12 000 名印度成年人进行的 rs12970134 荟萃分析证实了其与肥胖的关联（P
Common variants near melanocortin 4 receptor (MC4R) gene are shown to be associated with adiposity but have varied effects in different age groups. Among Indians, studies have shown association of these variants with obesity in adults, but their association in children is yet to be confirmed. We evaluated association of rs17782313 and rs12970134 near MC4R with adiposity and related traits in Indians including 1362 children and 4077 adults (consisting of 2049 diabetic and 2028 nondiabetic adult subjects). Both variants rs17782313 and rs12970134 showed strong association with adiposity measures (weight, body mass index and waist circumference) in children (P-range 7.6 x 10(-5)-3.8 x 10(-12)) and nominal association in nondiabetic adults (P-range 0.05-0.003). Effect sizes on adiposity measures in children (beta range 0.22-0.26 Z-score) were similar to 3-fold higher compared with adults (beta range 0.06-0.08). The minor alleles of both variants showed borderline association (P-range 0.08-0.04) with risk of type 2 diabetes in adults. Meta-analysis of rs12970134 in >12 000 Indian adults corroborated its association with adiposity (P