Minimal surface scaffold designs for tissue engineering
Minimal surface scaffold designs for tissue engineering
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DOI：
10.1016/j.biomaterials.2011.06.012
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发表时间：
2011-10-01
期刊：
影响因子：
14
通讯作者：
Schroeder-Turk, Gerd E.
中科院分区：
文献类型：
--
作者：
Kapfer, Sebastian C.;Hyde, Stephen T.;Schroeder-Turk, Gerd E.
与目前在组织工程文献中报道的相比，三周期最小表面被证明是生物形态支架设计的更通用的来源。讨论了基于最小表面的片状形态的支架结构，与传统设计相比具有显着的结构和机械优势。这些片状固体是通过将立方体最小表面膨胀为有限厚度的片状而获得的多孔固体，与最小表面形成固体/空隙界面的传统网络固体相反。使用有限元方法，片状固体的机械刚度被证明超过了传统的网络固体的体积分数和材料参数的范围很广。我们进一步讨论了机械性能的结构性能关系，可用于定制设计制造的快速成型。使用晶格玻尔兹曼计算的流体渗透性的支架的传输特性进行了分析。大量不同的最小表面，其中每一个都可以实现为片状或网状固体，并在不同的体积分数，提供了设计的灵活性至关重要的竞争设计目标的优化。(C)2011爱思唯尔有限公司保留所有权利。
Triply-periodic minimal surfaces are shown to be a more versatile source of biomorphic scaffold designs than currently reported in the tissue engineering literature. A scaffold architecture with sheetlike morphology based on minimal surfaces is discussed, with significant structural and mechanical advantages over conventional designs. These sheet solids are porous solids obtained by inflation of cubic minimal surfaces to sheets of finite thickness, as opposed to the conventional network solids where the minimal surface forms the solid/void interface. Using a finite-element approach, the mechanical stiffness of sheet solids is shown to exceed that of conventional network solids for a wide range of volume fractions and material parameters. We further discuss structure property relationships for mechanical properties useful for custom-designed fabrication by rapid prototyping. Transport properties of the scaffolds are analyzed using Lattice-Boltzmann computations of the fluid permeability. The large number of different minimal surfaces, each of which can be realized as sheet or network solids and at different volume fractions, provides design flexibility essential for the optimization of competing design targets. (C) 2011 Elsevier Ltd. All rights reserved.