The Therapeutic Potential of Chemokines in the Treatment of Chemotherapy-Induced Peripheral Neuropathy.
The Therapeutic Potential of Chemokines in the Treatment of Chemotherapy-Induced Peripheral Neuropathy.
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DOI：
10.2174/1389450120666190906153652
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发表时间：
2020-02
影响因子：
3.2
通讯作者：
Lin Zhou;Lu-yao Ao;Yun-yi Yan;Wan-ting Li;An-qi Ye;Yahui Hu;W. Fang;Yunman Li
中科院分区：
文献类型：
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作者：
Lin Zhou;Lu-yao Ao;Yun-yi Yan;Wan-ting Li;An-qi Ye;Yahui Hu;W. Fang;Yunman Li
癌症治疗的当前挑战和并发症之一是化疗诱导的周围神经病变（CIPN）和与这种病症相关的神经性疼痛。许多主要的化疗药物可引起神经毒性，显著调节免疫系统，并总是伴随着各种不良反应。最近的证据表明，在用化疗剂治疗期间，神经系统和免疫系统之间发生串扰;因此，一个新兴的概念是神经炎症是CIPN的主要机制之一，如通过趋化因子的上调所证明的。趋化因子最初被鉴定为外周免疫细胞运输的调节剂，并且趋化因子也在中枢神经系统（CNS）中的神经元和胶质细胞上表达。目的在本文中，我们收集的证据表明，趋化因子是潜在的介质和贡献者的疼痛信号在CIPN。趋化因子及其受体，如CX 3CL 1/CX 3CR 1、CCL 2/CCR 2、CXCL 1/CXCR 2、CXCL 12/CXCR 4和CCL 3/CCR 5的表达在CIPN的病理条件下改变，并且趋化因子受体拮抗剂减弱神经性疼痛行为。结论通过对趋化因子介导的通讯机制的研究，我们有可能发现趋化因子的作用靶点，从而为CIPN的治疗提供新的策略。
BACKGROUND One of the current challenges and complications of cancer therapy is chemotherapy-induced peripheral neuropathy (CIPN) and the neuropathic pain that is associated with this condition. Many major chemotherapeutic agents can cause neurotoxicity, significantly modulate the immune system and are always accompanied by various adverse effects. Recent evidence suggests that cross-talk occurs between the nervous system and the immune system during treatment with chemotherapeutic agents; thus, an emerging concept is that neuroinflammation is one of the major mechanisms underlying CIPN, as demonstrated by the upregulation of chemokines. Chemokines were originally identified as regulators of peripheral immune cell trafficking, and chemokines are also expressed on neurons and glial cells in the central nervous system (CNS). OBJECTIVE In this review, we collect evidence demonstrating that chemokines are potential mediators and contributors to pain signalling in CIPN. The expression of chemokines and their receptors, such as CX3CL1/CX3CR1, CCL2/CCR2, CXCL1/CXCR2, CXCL12/CXCR4 and CCL3/CCR5, is altered in the pathological conditions of CIPN, and chemokine receptor antagonists attenuate neuropathic pain behaviour. CONCLUSION By understanding the mechanisms of chemokine-mediated communication, we may reveal chemokine targets that can be used as novel therapeutic strategies for the treatment of CIPN.