A MOUSE MACROPHAGE FACTOR INDUCED HEAD STRUCTURES AND ORGANIZES A BODY AXIS IN XENOPUS
A MOUSE MACROPHAGE FACTOR INDUCED HEAD STRUCTURES AND ORGANIZES A BODY AXIS IN XENOPUS
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DOI：
10.1126/science.2382134
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发表时间：
1990-08-03
期刊：
影响因子：
56.9
通讯作者：
MELTON, DA
中科院分区：
文献类型：
--
作者：
SOKOL, S;WONG, GG;MELTON, DA
可溶性多肽因子被认为是脊椎动物胚胎诱导的诱导剂。在这里，一种由小鼠巨噬细胞株分泌的蛋白质(PIF)被证明改变了非洲爪哇胚胎细胞的发育命运。暴露于PIF会导致假定的外胚层外植体形成包括大脑和眼睛在内的前神经和中胚层组织，而不是纤毛表皮。此外，诱导的组织被组织成一个发育的胚轴。这些结果表明，PIF或一个密切相关的分子参与了前结构的诱导和青蛙身体计划的组织。
Soluble peptide factors have been implicated as the agents responsible for embryonic inductions in vertebrates. Here, a protein (PIF) secreted by a mouse macrophage cell line is shown to change the developmental fate of Xenopus embryonic cells. Exposure to PIF causes presumptive ectodermal explants to form anterior neural and mesodermal tissues, including brain and eye, instead of ciliated epidermis. In addition, the induced tissues are organized into a rudimentary embryonic axis. These results suggest that PIF or a closely related molecule is involved in inducing anterior structures and organizing the frog body plan.