The Effect of an Online Cognitive Training Package in Healthy Older Adults: An Online Randomized Controlled Trial
The Effect of an Online Cognitive Training Package in Healthy Older Adults: An Online Randomized Controlled Trial
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DOI：
10.1016/j.jamda.2015.06.014
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发表时间：
2015-11-01
影响因子：
7.6
通讯作者：
Ballard, Clive
中科院分区：
文献类型：
--
作者：
Corbett, Anne;Owen, Adrian;Ballard, Clive
认知训练（CT）为老年人痴呆症的预防和认知功能的维持提供了一种潜在的方法。在线交付提供了一个具有成本效益的手段，实施CT相比，在人的干预措施，提供了一个有效的公共卫生干预的潜在风险reduction.Methods：一个双盲6个月的在线随机对照试验，在成年人超过50岁的随机一般CT，推理CT，或控制。主要结果是60岁以上成年人的工具性日常生活活动（IADL）。次要结果是推理，言语短期记忆，空间工作记忆，言语学习（VL），和数字警戒50岁以上的成年人。二次分析进行了一组定义为显示年龄相关的损害推理根据基线分数在这个domain.Results：共2912名成年人年龄超过60岁（6742 > 50）参加。在6个月时，一般和推理包使IADL（P = .008，P = .011），推理（P < 0.0001，P < .0001）和VL（P = .007，P = .008）受益。从6周开始，推理的益处是明显的。6个月内开发的其他好处。对年龄相关性损伤参与者的分析也显示了相同的获益模式。一个明确的剂量-反应效应seen.Conclusions：在线CT赋予显着的好处，认知和功能的老年人，有利于推理包。受益规模与面对面培训相当，表明其作为公共卫生干预措施的潜力。对年龄相关性损伤组的影响表明对这一高危组特别敏感，值得进一步调查。(C)2015年AMDA -急性后和长期护理医学协会。
Introduction: Cognitive training (CT) offers a potential approach for dementia prevention and maintenance of cognitive function in older adults. Online delivery provides a cost-effective means of implementing CT compared with in-person interventions, with the potential of providing an effective public health intervention for risk reduction.Methods: A double-blind 6-month online randomized controlled trial in adults older than 50 randomized to General CT, Reasoning CT, or control. The primary outcome was instrumental activities of daily living (IADL) in adults older than 60. Secondary outcomes were reasoning, verbal short-term memory, spatial working memory, verbal learning (VL), and digit vigilance in adults older than 50. Secondary analyses were performed with a group defined as showing age-associated impairment in reasoning according to baseline scores in this domain.Results: A total of 2912 adults older than 60 (6742 > 50) participated. General and reasoning packages conferred benefit to IADL (P = .008, P = .011), reasoning (P < 0.0001, P < .0001), and VL (P = .007, P = .008) at 6 months. Benefit in reasoning was evident from 6 weeks. Other benefits developed over 6 months. Analysis of participants with age-associated impairment also showed the same pattern of benefit. A clear dose-response effect was seen.Conclusions: Online CT confers significant benefit to cognition and function in older adults, with benefit favoring the Reasoning package. Scale of benefit is comparable with in-person training, indicating its potential as a public health intervention. Impact on the group with age-associated impairment indicates a particular sensitivity to this at-risk group, which merits further investigation. (C) 2015 AMDA - The Society for Post-Acute and Long-Term Care Medicine.