Host Determinants of Influenza RNA Synthesis
Host Determinants of Influenza RNA Synthesis
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DOI：
10.1146/annurev-virology-092917-043339
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Barclay, Wendy S.
中科院分区：
文献类型：
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作者：
Peacock, Thomas P.;Sheppard, Carol M.;Barclay, Wendy S.
流感病毒是造成季节性和大流行性呼吸道疾病的主要原因。流感是一种负义单链RNA病毒，其自身编码RNA依赖性RNA聚合酶（RdRp）用于核酸合成。RdRp通过一个互补的RNA中间体催化mRNA合成，以及病毒基因组（病毒RNA）的复制。病毒的繁殖需要以一种受控的方式产生这些RNA物种，同时与宿主细胞激烈竞争资源。流感病毒利用宿主因子在RNA合成的每一步增强和调节RdRp活性。本文综述了这些宿主因子，并总结了我们目前对它们在病毒RNA合成中所起作用的理解。
Influenza viruses are a leading cause of seasonal and pandemic respiratory illness. Influenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for nucleic acid synthesis. The RdRp catalyzes mRNA synthesis, as well as replication of the virus genome (viral RNA) through a complementary RNA intermediate. Virus propagation requires the generation of these RNA species in a controlled manner while competing heavily with the host cell for resources. Influenza virus appropriates host factors to enhance and regulate RdRp activity at every step of RNA synthesis. This review describes such host factors and summarizes our current understanding of the roles they play in viral synthesis of RNA.