Age-related changes in insulin-like growth factor I and II in human femoral cortical bone: lack of correlation with bone mass.
Age-related changes in insulin-like growth factor I and II in human femoral cortical bone: lack of correlation with bone mass.
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DOI：
10.1016/s8756-3282(98)00186-0
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发表时间：
1999-04
期刊：
影响因子：
4.1
通讯作者：
T. Seck;A. Bretz;R. Krempien;B. Krempien;R. Ziegler;J. Pfeilschifter
中科院分区：
文献类型：
--
作者：
T. Seck;A. Bretz;R. Krempien;B. Krempien;R. Ziegler;J. Pfeilschifter
人皮质骨中胰岛素样生长因子-I（IGF-I）的浓度随着年龄的增长而下降，但这种下降与皮质骨转换和骨量的相关性尚不清楚。在本研究中，我们同时评估了IGF-I和-II的浓度在皮质骨基质和组织形态计量学参数的骨量和骨转换在125个样本的近端人股骨干。骨宽度减少了27%，孔隙度增加了100%，女性皮质骨之间的第四和第九个十年。类似但较弱的变化往往发生在雄性皮质骨中。这两种IGF的浓度与骨单位进行骨重建的百分比相关。然而，尽管与年龄相关的减少，在两种IGF的男性和IGF-I的女性，无论是IGFs占年龄相关的或年龄无关的变化，在皮质孔隙度或骨宽度。总之，这些数据表明，局部浓度的IGF-I和-II相关的皮质骨转换。与此相反，我们的研究提供了一个主要的作用，骨基质IGF-I和IGF-II的决定因素，在老年人的皮质骨质量的证据。IGF系统的其他成分是否可能是皮质骨丢失的更强决定因素仍有待确定。
The concentration of insulin-like growth factor-I (IGF-I) in human cortical bone declines with age, but the relevance of this decline for cortical bone turnover and bone mass is unknown. In the present study, we simultaneously assessed the concentration of IGF-I and -II in cortical bone matrix and histomorphometric parameters of bone mass and bone turnover in 125 samples from the proximal human femur shaft. Bone width decreased by 27% and porosity increased by 100% in female cortical bone between the fourth and the ninth decade. Similar, but weaker, changes tended to occur in male cortical bone. The concentrations of both IGF species were correlated with the percentage of osteons undergoing bone remodeling. However, despite age-related decreases in both IGF species in men and in IGF-I in women, neither of the IGFs accounted for age-related or age-independent variability in cortical porosity or bone width. In conclusion, these data suggest that the local concentrations of IGF-I and -II are related to cortical bone turnover. In contrast, our study provides no evidence for a major role of bone matrix IGF-I and -II as determinants of cortical bone mass in elderly individuals. Whether other components of the IGF system may be stronger determinants of cortical bone loss remains to be determined.