Plasma vitamin C levels in men and women from different ethnic backgrounds living in England
Plasma vitamin C levels in men and women from different ethnic backgrounds living in England
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DOI：
10.1093/ije/28.3.450
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发表时间：
1999-06-01
影响因子：
7.7
通讯作者：
Cook, DG
中科院分区：
文献类型：
--
作者：
Ness, AR;Cappuccio, FP;Cook, DG
背景居住在英国的南亚裔人因冠心病的死亡率比白人高。造成这些差异的原因还没有完全弄清楚。方法在一项基于人群的横断面研究中，我们比较了1018名40-59岁的男性和女性(455名男性，563名女性，328名南亚人，355名非洲裔，335名白人)的血浆维生素C水平，并考虑了潜在的混杂因素。在调整了年龄、体重指数、吸烟、服用补充剂和素食等因素后，平均血浆维生素C水平白人男性为38.8mMol/L，非洲裔男性为36.5mMol/L，南亚裔男性为32.9mMol/L(协方差分析P=0.033)。在女性中，调整后的平均血浆维生素C水平白人为52.4(1.6mU/L)，非洲裔为46.0mU/m o l/L，南亚人为37.3mU/m o l/L(P<；0.0001经协方差分析)。南亚人无论是男性(差异6.4[95%CI：1.5，11.3]MU/L)和女性(16.8[95%CI：11.5，22.1]MU/L)均低于白人。南亚女性，而不是男性，也低于非洲人后裔(8.8[95%CI：4.5，13.1]Mol/L)。非洲女性，而不是男性，比白人女性低(6.6[95%CI：2.3；10.9]Mol/L)。加勒比海人和西非人之间以及南亚印度教徒和穆斯林之间没有显著差异。结论这些数据表明英国不同种族之间存在着重要的维生素C饮食差异。南亚人之间的较大差异可能是导致他们患冠心病风险增加的原因之一。
Background People of South Asian origin living in the UK have higher death rates due to coronary heart disease than whites. The reasons for these differences are not fully understood. Previous attempts to relate diet to cardiovascular risk in South Asians have been inconclusive.Methods We compared the levels of plasma vitamin C in a cross-sectional population-based study of 1018 men and women aged 40-59 (455 men, 563 women, 328 South Asians, 355 of African descent, 335 whites) co-resident in a geographically defined area of South London, when allowing for potential confounders.Results Pasting plasma vitamin C levels were significantly higher in women, vegetarians, supplement takers and non-smokers. After adjustment for age, body mass index, current smoking, supplement use and vegetarianism the mean plasma vitamin C levels were 38.8 (SE 1.6) mu mol/l in white men, 36.5 (1.6) mu mol/l in men of African descent and 32.9 (1.5) mu mol/l in South Asian men (P = 0.033 by analysis of covariance). In women the adjusted mean plasma vitamin C levels were 52.4 (1.6) mu mol/l in whites, 46.0 (1.4) mu mol/l in women of African descent and 37.3 (1.8) mu mol/l in South Asians (P < 0.0001 by analysis of covariance). South Asians had lower levels than whites in both men (difference 6.4 [95% CI : 1.5, 11.3] mu mol/l) and women (16.8 [95% CI: 11.5, 22.1] mu mol/l). South Asian women, but not men, also had lower levels than those of African descent (8.8 [95% CI : 4.5, 13.1] mu mol/l). African women, but not men, had lower levels than white women (6.6 [95% CI : 2.3; 10.9] mu mol/l). No significant differences were seen between Caribbeans and West Africans or between South Asian Hindus and Muslims.Conclusions These data suggest that important dietary differences in vitamin C exist between different ethnic groups living in England. The larger differences in South Asians may contribute to their increased coronary risk.