MURINE BONE MORPHOGENETIC PROTEIN-4 GENE - EXISTENCE OF MULTIPLE PROMOTERS AND EXONS FOR THE 5'-UNTRANSLATED REGION
MURINE BONE MORPHOGENETIC PROTEIN-4 GENE - EXISTENCE OF MULTIPLE PROMOTERS AND EXONS FOR THE 5'-UNTRANSLATED REGION
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DOI：
10.1006/bbrc.1993.1523
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发表时间：
1993-05-14
影响因子：
3.1
通讯作者：
NAKAZATO, H
中科院分区：
文献类型：
--
作者：
KURIHARA, T;KITAMURA, K;NAKAZATO, H
已分离到一个约16kb的小鼠基因组克隆，可能包含完整的骨形态发生蛋白(BMP)-4基因。与克隆的比较表明，克隆的3‘端至少有5个外显子。有两个可供选择的转录起始点，一个是第一个外显子，另一个是第二外显子，其结果是mRNA中的外显子组织分别是I-III-IV-V和II-III-IV-V。编码区分布在外显子IV和V之间，两个启动子区域都没有标准的TATA盒，但携带富含GC的序列。
A murine genomic clone of about 16 kilobases encompassing putatively entire bone morphogenetic protein (BMP)-4 gene has been isolated. Comparison with the cDNA clones revealed the existence of at least five exons on the 3′ side of the clone. There are two alternative transcriptional start sites, one is for the first exon the other for the second, the resulting exon organization in mRNA is I-III-IV-V and II-III-IV-V, respectively. The coding region is dispersed between exons IV and V. Both promoter regions carry no canonical TATA box but carry GC rich sequences.