Diabetes and the severity of pandemic influenza A (H1N1) infection.
Diabetes and the severity of pandemic influenza A (H1N1) infection.
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DOI：
10.2337/dc09-2215
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发表时间：
2010-07
期刊：
影响因子：
16.2
通讯作者：
Tannenbaum TN
中科院分区：
文献类型：
--
作者：
Allard R;Leclerc P;Tremblay C;Tannenbaum TN
确认糖尿病患者中存在甲型H1N1流感并发症风险增加的情况。使用加拿大蒙特利尔加强的流感监测项目的数据和糖尿病患病率的年龄/性别特定人口估计，我们估计了糖尿病患者的住院风险。将入院或未入院的患者与重症监护病房(ICU)进行比较，我们估计了与糖尿病相关的ICU入院风险，并控制了其他患者特征。在239名经聚合酶链式反应确诊的甲型H1N1流感住院患者中，162人(68%)接受了访谈，其中22人患有糖尿病，预计为7.1人(患病率为3.10[95%可信区间2.04-4.71])。与非糖尿病住院患者相比，糖尿病住院患者入院ICU的优势比为4.29(95%可信区间1.29~14.3)。糖尿病使甲型H1N1流感后住院的风险增加了三倍，住院后住进ICU的风险增加了四倍。
To confirm the existence of an increased risk of complications from influenza A (H1N1)p among patients with diabetes. Using data from an enhanced influenza surveillance project in Montreal, Canada, and age/sex-specific population estimates of diabetes prevalence, we estimated the risk of hospitalization among persons with diabetes. Comparing hospitalized patients admitted or not to an intensive care unit (ICU), we estimated the risk of ICU admission associated with diabetes, controlling for other patient characteristics. Among 239 hospitalized patients with PCR-confirmed influenza A (H1N1)p, 162 (68%) were interviewed, of whom 22 had diabetes, when 7.1 were expected (prevalence ratio 3.10 [95% CI 2.04–4.71]). The odds ratio for ICU admission was 4.29 (95% CI 1.29–14.3) among hospitalized patients with diabetes compared to those without. Diabetes triples the risk of hospitalization after influenza A (H1N1)p and quadruples the risk of ICU admission once hospitalized.
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