Gene regulation by Y-box proteins: coupling control of transcription and translation
Gene regulation by Y-box proteins: coupling control of transcription and translation
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DOI：
10.1016/s0962-8924(98)01300-2
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发表时间：
1998-08-01
影响因子：
19
通讯作者：
Wolffe, AP
中科院分区：
文献类型：
--
作者：
Matsumoto, K;Wolffe, AP
Y-box蛋白是基因表达的多功能调节剂。在体细胞中，它们有能力对转录和翻译产生积极和消极的影响。在非洲爪蟾卵母细胞中，它们有助于掩盖母体mRNA，并将细胞核中mRNA的转录与细胞质中的翻译命运结合起来。这篇综述描述了Y-box蛋白破坏RNA和DNA双链的能力，以及它们在细胞核和细胞质间的分布，可能解释了这些多重作用。
Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have the capacity to exert positive and negative effects on both transcription and translation. In Xenopus oocytes, they help to mask maternal mRNA and couple the transcription of mRNA in the nucleus to its translational fate in the cytoplasm. This review describes how the capacity of the Y-box proteins to destabilize both RNA and DNA duplexes, together with their distribution between nuclear and cytoplasmic compartments, might explain these multiple roles.