Sleep apnea, APOE4 and Alzheimer's disease 20 years and counting?
Sleep apnea, APOE4 and Alzheimer's disease 20 years and counting?
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DOI：
10.1016/s0022-3999(02)00436-1
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发表时间：
2002-07-01
影响因子：
4.7
通讯作者：
Bliwise, DL
中科院分区：
文献类型：
--
作者：
Bliwise, DL
阿尔茨海默病（AD）被认为至少部分是遗传性的，这种疾病的关键基因型标记之一是APOE4等位基因。睡眠呼吸暂停和AD之间的联系一直被怀疑，因为在一些睡眠呼吸暂停患者中观察到的精神障碍和可能的证据表明一些痴呆患者的睡眠呼吸暂停率较高。最近证明APOE4基因型和睡眠呼吸暂停之间的关联重新点燃了对这一主题的进一步兴趣，特别是因为睡眠呼吸暂停的特征是多种遗传脆弱性。我们在此回顾了睡眠呼吸暂停与痴呆之间相关性的证据，APOE 4作为脑血管疾病可能标志物的作用，并讨论了与睡眠呼吸暂停作为痴呆潜在可逆原因相关的治疗考虑。(C)2002年爱思唯尔科技有限公司All rights reserved.
Alzheimer's disease (AD) is acknowledged to be at least partially genetic, and one of the key genotypic markers for this condition is the APOE4 allele. Links between sleep apnea and AD have long been suspected because of mental impairment seen in some sleep apnea patients and possible evidence suggesting higher rates of sleep apnea in some dementia patients. The recent demonstration of an association between the APOE4 genotype and sleep apnea has rekindled further interest in this topic, particularly because sleep apnea is characterized by multiple genetic vulnerabilities. We review here evidence related to associations between sleep apnea and dementia, the role of APOE4 as a likely marker for cerebrovascular disease, and discuss treatment considerations relevant to sleep apnea as a potentially reversible cause of dementia. (C) 2002 Elsevier Science Inc. All rights reserved.