Neural correlates of active avoidance behavior in superior colliculus.
Neural correlates of active avoidance behavior in superior colliculus.
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DOI：
10.1523/jneurosci.1497-10.2010
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发表时间：
2010-06-23
期刊：
影响因子：
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通讯作者：
Castro-Alamancos MA
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文献类型：
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作者：
Cohen JD;Castro-Alamancos MA
主动回避有害情况似乎是高度适应性的，但潜在的神经机制在很大程度上是未知的。在主动回避过程中，大鼠可以有效地利用上丘探测到一个突出的须状条件刺激（WCS），这是一个厌恶事件的信号。本研究记录了大鼠主动回避行为时上丘中间层的单位电位和场电位活动。在WCS发生前的一段时间内，逃避比逃避（不成功的逃避）与更高的放电率相关，这表明准备好的上丘更有可能检测到WCS并导致逃避。此外，在WCS期间，观察到在试验中导致避免的总体射击率的强劲上升。发射速率的陡增不是由于穿梭，而可能用于驱动下游电路以避免。因此，在上丘中发现了主动回避行为的强大神经关联，强调了其在检测需要立即采取行动的显著感觉信号中的作用。
Active avoidance of harmful situations seems highly adaptive, but the underlying neural mechanisms are largely unknown. Rats can effectively use the superior colliculus during active avoidance to detect a salient whisker conditioned stimulus (WCS) that signals an aversive event. Here, we recorded unit and field potential activity in the intermediate layers of the superior colliculus of rats during active avoidance behavior. During the period preceding the onset of the WCS, avoids are associated with a higher firing rate than escapes (unsuccessful avoids), indicating that a prepared superior colliculus is more likely to detect the WCS and lead to an avoid. Moreover, during the WCS, a robust ramping up of overall firing rate is observed for trials leading to avoids. The firing rate ramping is not due to shuttling, and may serve to drive downstream circuits to avoid. Therefore, a robust neural correlate of active avoidance behavior is found in the superior colliculus, emphasizing its role in the detection of salient sensory signals that require immediate action.