Preclinical non-human models to combat dementia.
Preclinical non-human models to combat dementia.
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DOI：
10.5214/ans.0972.7531.200109
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发表时间：
2013-01
影响因子：
1.5
通讯作者：
Anand A
中科院分区：
文献类型：
--
作者：
Banik A;Anand A
痴呆症的特征是一定程度的记忆丧失和智力功能障碍，主要表现为阿尔茨海默病。其根本原因包括基因突变、生活方式因素和其他环境影响，以及脑损伤和正常衰老。虽然已经有许多啮齿动物和非人灵长类动物模型由各种药物，神经毒素和基因消融创建，但目前的情况并没有表现出良好的表征动物模型，以评估新的化合物和各种治疗策略的痴呆症。因此，非常需要一种表现出接近该综合征的病理和神经行为参数的综合模型。本文讨论了建立痴呆动物模型的各种实验策略。
Dementia is characterized by a certain degree of memory loss with disabled intellectual functioning, which mostly presents as Alzheimer’s disease. The underlying causes range from gene mutations, lifestyle factors, and other environmental influences to brain injuries and normal aging. Although there have been many rodent and non-human primate models created by various drugs, neurotoxins and genetic ablation but the current scenario does not exhibit a well characterized animal model to evaluate novel compounds and various treatment strategies for dementia. Therefore, a comprehensive model exhibiting the pathologies and neuro-behavioral parameters close to this syndrome is very much needed. This report discusses the various experimental strategies to create animal models of dementia.