Reduced chaos of interspike interval of midbrain dopaminergic neurons in aged rats
Reduced chaos of interspike interval of midbrain dopaminergic neurons in aged rats
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DOI：
10.1016/s0306-4522(98)00702-7
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发表时间：
1999-04-01
期刊：
影响因子：
3.3
通讯作者：
Esposito, E
中科院分区：
文献类型：
--
作者：
Di Mascio, M;Di Giovanni, G;Esposito, E
在这项研究中，非线性预测方法结合高斯尺度的替代数据被用来量化，作为第一个目标，混沌行为的腹侧被盖区多巴胺能神经元，细胞外记录在体内，在麻醉大鼠的interspike间隔。第二个目标是确定混沌内容的差异作为年龄的函数。比较了三组不同的抹布：年轻（2至4周龄），成年（3至4个月大）和老年（16-19个月大）。已经发现，动作电位序列的复杂程度随着年龄的增长而降低。每组内腹侧被盖区多巴胺神经元的混沌内容以及混沌随年龄的减少不能用神经元活动的标准特征（放电率、爆发活动）来解释。这些数据可以合理化的确定性混沌的作用，在复杂的生物系统的功能行为的最新研究结果，并表明，非线性分析可以提供一个额外的方法来表征神经元的活动。(C)1999年IBRO。出版社：Elsevier Science Ltd
In this study, the nonlinear prediction method combined with Gaussian-scaled surrogate data was used to quantify, as a first goal, the chaotic behavior of the interspike interval of ventral tegmental area dopaminergic neurons, extracellularly recorded in vivo, in anesthetized rats. The second goal was to determine the differences in chaotic content as a function of age. Comparisons were made among three different groups of rag: young (two to four weeks of age), adult (three to four months of age) and aged (16-19 months of age). It has been found that the degree of complexity of action potential trains is reduced with aging. The chaotic content of ventral tegmental area dopamine neurons within each group and the decrease of chaos with aging cannot be explained in terms of standard characteristics of neuronal activity (firing rate, bursting activity). These data can be rationalized in the light of recent findings on the role of deterministic chaos in the functional behavior of complex biological systems, and suggests that nonlinear analysis may provide an additional method in characterizing neuronal activity. (C) 1999 IBRO. Published by Elsevier Science Ltd.