Deficits in trace fear conditioning induced by neonatal alcohol persist into adulthood in female rats.
Deficits in trace fear conditioning induced by neonatal alcohol persist into adulthood in female rats.
复制标题
DOI：
10.1002/dev.21035
复制
发表时间：
2013-05
影响因子：
2.2
通讯作者：
W. Schreiber;P. Hunt
中科院分区：
文献类型：
--
作者：
W. Schreiber;P. Hunt
发育中的海马体特别容易受到酒精的毒性影响，并且在啮齿动物的新生儿酒精暴露后，已经报道了海马体依赖性任务的行为缺陷。在此之前，我们已经发现，在出生后4-9天（PD）暴露于酒精的大鼠中，微量恐惧条件反射（一种依赖于大脑皮层的学习任务）被破坏，尽管延迟恐惧条件反射没有被破坏。目前的研究表明，这种损害的痕迹恐惧条件反射，以前只在青春期测量，持续到成年期，但只在女性。动物在PD 4-9暴露于5.0 g/kg/天酒精，并在PD 30或65进行训练。在PD 30时，酒精暴露显著损害了两种性别的痕量条件反射。在成年训练的动物中，仅在雌性受试者中观察到痕量缺陷，这表明尽管雄性表现出与年龄相关的功能恢复，但酒精诱导的痕量条件反射缺陷在雌性Sprague-Dawley大鼠中更持久。
The developing hippocampus is particularly vulnerable to the toxic effects of alcohol, and behavioral deficits on hippocampus-dependent tasks have been reported following neonatal alcohol exposure in rodents. Previously, we have found that trace fear conditioning (a hippocampus-dependent learning task) is disrupted in rats exposed to alcohol during postnatal days (PD) 4-9, although delay fear conditioning is not. The present study indicates that this impairment in trace fear conditioning, previously only measured during adolescence, persists into adulthood but only in females. Animals were exposed to 5.0 g/kg/day alcohol on PD 4-9 and were trained on either PD 30 or 65. Alcohol exposure significantly impaired trace conditioning in both sexes at PD 30. In animals trained as adults, the deficit in trace was only observed in female subjects, suggesting that although males exhibit an age-related recovery of function, alcohol-induced trace conditioning deficits are more persistent in female Sprague-Dawley rats.