MicroRNA networks direct neuronal development and plasticity.
MicroRNA networks direct neuronal development and plasticity.
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DOI：
10.1007/s00018-011-0788-1
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发表时间：
2012-01
影响因子：
8
通讯作者：
Aschrafi, A.
中科院分区：
文献类型：
--
作者：
Loohuis, N. F. M. Olde;Kos, A.;Martens, G. J. M.;Van Bokhoven, H.;Kasri, N. Nadif;Aschrafi, A.
MicroRNA（miRNAs）是一类小的非编码RNA，在基因表达中起转录后调节作用。在神经元中，单个miRNA的功能才刚刚开始出现，最近的研究已经阐明了神经miRNA在神经元发育和成熟的各个阶段的作用，包括轴突生长，树突发生和棘形成。值得注意的是，miRNAs在轴体和突触树突区室中局部调节mRNA翻译，从而有助于轴突和树突结构及其功能的动态空间组织。鉴于miRNA在调节早期脑发育和介导以后生活中的突触可塑性中的关键作用，很容易推测神经系统疾病的病理学受到miRNA表达或功能改变的影响。在这里，我们提供了一个概述最近确定的神经元发育和可塑性的机制，涉及miRNA，和miRNA失调的后果。
MicroRNAs (miRNAs) constitute a class of small, non-coding RNAs that act as post-transcriptional regulators of gene expression. In neurons, the functions of individual miRNAs are just beginning to emerge, and recent studies have elucidated roles for neural miRNAs at various stages of neuronal development and maturation, including neurite outgrowth, dendritogenesis, and spine formation. Notably, miRNAs regulate mRNA translation locally in the axosomal and synaptodendritic compartments, and thereby contribute to the dynamic spatial organization of axonal and dendritic structures and their function. Given the critical role for miRNAs in regulating early brain development and in mediating synaptic plasticity later in life, it is tempting to speculate that the pathology of neurological disorders is affected by altered expression or functioning of miRNAs. Here we provide an overview of recently identified mechanisms of neuronal development and plasticity involving miRNAs, and the consequences of miRNA dysregulation.
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影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
影响因子：
5.3
作者：
Davis, Tigwa H.;Cuellar, Trinna L.;Ullian, Erik M.
通讯作者：
Ullian, Erik M.
影响因子：
10.5
作者：
Babiarz, Joshua E.;Ruby, J. Graham;Blelloch, Robert
通讯作者：
Blelloch, Robert
DOI：
10.1126/science.1190809
发表时间：
2010-06-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cifuentes D;Xue H;Taylor DW;Patnode H;Mishima Y;Cheloufi S;Ma E;Mane S;Hannon GJ;Lawson ND;Wolfe SA;Giraldez AJ
通讯作者：
Giraldez AJ
影响因子：
3.5
作者：
Christensen M;Larsen LA;Kauppinen S;Schratt G
通讯作者：
Schratt G