Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation
Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation
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DOI：
10.1016/s0049-3848(02)00334-1
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发表时间：
2002-09-01
影响因子：
7.5
通讯作者：
McDonagh, PF
中科院分区：
文献类型：
--
作者：
Cohen, Z;Gonzales, RF;McDonagh, PF
糖尿病患者患有许多并发症，包括血栓前病症。活化的血小板膜提供了一个锚，磷脂酰丝氨酸，用于凝血酶原酶复合物的附着，从而增加凝血酶的形成。本研究旨在进一步阐明2型糖尿病患者血液中凝血蛋白和活化血小板之间的相互关系。我们发现，与年龄匹配的对照组相比，2型糖尿病患者（ZDF）血液中的凝血酶活性显著增加（30倍）（p
Diabetics suffer from many complications including a prothrombotic condition. Activated platelet membrane provides an anchor, phosphatidylserine, for the attachment of the prothrombinase complex, which allows increased thrombin formation. This study aimed to further elucidate the interrelationship between coagulation proteins and activated platelets in type 2 diabetic blood. We found that there vas a significant increase (30x) in thrombin activity in the type 2 diabetic (ZDF) blood as compared to age-matched (ZL) controls (p