Lifestyles, left atrial structure and function, and cognitive decline in adults with the metabolic syndrome.
Lifestyles, left atrial structure and function, and cognitive decline in adults with the metabolic syndrome.
复制标题
患有代谢综合征的成年人的生活方式、左心房结构和功能以及认知能力下降。
DOI：
10.1101/2023.06.23.23291821
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Alonso,Alvaro
中科院分区：
文献类型：
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作者：
Casanova,InesGonzalez;Alonso-Gómez,ÁngelM;Romaguera,Dora;Toledo,Estefanía;Li,Linzi;Fortuny,Elena;López,Luis;Ramallal,Raúl;Salas-Salvadó,Jordi;Tojal-Sierra,Lucas;Castañer,Olga;Alonso,Alvaro
证据支持生活方式（包括饮食和身体活动）和体重与认知功能的关联，但导致这些关联的途径尚未完全阐明。由于健康的生活方式与更好的左心房结构和功能相关，而左心房结构和功能又与更好的认知功能相关，因此我们验证了左心房结构和功能是生活方式与认知之间关联的潜在中介的假设。我们纳入了476名来自西班牙三个中心的超重或肥胖代谢综合征患者。这些参与者在基线时接受了生活方式评估和经胸超声心动图检查，并在基线和两年随访时进行了执行功能测量的Trail Making A测试的重复测量。我们进行了中介分析，以测试左心房结构和功能的测量是否介导了地中海饮食评分、体力活动和基线体重之间的关联，以及两年内Trail Making a评分的变化。分析没有发现这些因素与Trail Making A评分之间存在关联，超声心动图测量也没有间接影响。本分析中样本量有限是一个局限性，应该进行更大规模的研究，以确定潜在的心血管因素介导生活方式和认知之间的关联。
Evidence supports associations of lifestyle (including diet and physical activity) and weight with cognitive functioning, but the pathways responsible for these associations have not been fully elucidated. Because healthier lifestyles have been associated with better left atrial structure and function, which in turn is associated with better cognitive functioning, we tested the hypothesis that left atrial structure and function is a potential mediator of the association between lifestyle and cognition. We included 476 participants classed as overweight or obese with metabolic syndrome from three centers in Spain. These participants underwent lifestyle assessments and transthoracic echocardiography at baseline and repeated measurements of the Trail Making A test, a measure of executive function, taken at baseline and at the two-year follow-up. We conducted mediation analyses to test if measures of left atrial structure and function mediated associations between adherence to the Mediterranean diet scores, physical activity, and weight at baseline, as well as a two-year change in Trail Making A scores. The analysis did not find an association between these factors and Trail Making A scores, and no indirect effects appeared to be mediated by echocardiographic measurements. The modest sample size in this analysis is a limitation, and larger studies should be conducted to determine potential cardiovascular factors mediating the association between lifestyle and cognition.