Complement activation in patients with neuromyelitis optica
Complement activation in patients with neuromyelitis optica
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DOI：
10.1016/j.jneuroim.2014.07.001
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发表时间：
2014-09-15
影响因子：
3.3
通讯作者：
Trendelenburg, Marten
中科院分区：
文献类型：
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作者：
Nytrova, Petra;Potlukova, Eliska;Trendelenburg, Marten
补体的作用已经在视神经脊髓炎(NMO)的实验模型中得到证实，然而，只有少数研究纵向分析了NMO患者的补体成分。我们测定了抗C1q抗体、补体裂解产物C3a、C4a和可溶性C5b-9在NMO患者、多发性硬化症患者和健康对照组的血清或血浆浓度。NMO患者的C3a和抗C1q抗体水平高于健康对照组。补体C3a水平与NMO患者的疾病活动性、神经功能障碍及水通道蛋白-4免疫球蛋白相关，提示补体替代途径在NMO发病机制中的作用，并支持治疗补体抑制的策略。(C)2014爱思唯尔B.V.保留所有权利。
The role of complement has been demonstrated in experimental models of neuromyelitis optics (NMO), however, only few studies have analysed complement components longitudinally in NMO patients. We measured serum or plasma concentrations of anti-C1q antibodies and complement split products C3a and C4a and soluble C5b-9 in patients with NMO, multiple sclerosis and healthy controls. NMO patients had higher levels of C3a and anti-C1q antibodies than healthy controls. C3a levels correlated with disease activity, neurological disability and aquaporin-4 IgG in NMO patients suggesting a role of the alternative pathway of complement in the pathogenesis of NMO and supporting the strategy of therapeutic complement inhibition. (C) 2014 Elsevier B.V. All rights reserved.