Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides
Ribosomal synthesis of dehydrobutyrine- and methyllanthionine-containing peptides
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DOI：
10.1039/b904314d
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Suga, Hiroaki
中科院分区：
文献类型：
--
作者：
Goto, Yuki;Iwasaki, Kazuhiro;Suga, Hiroaki
我们在这里报道了核糖体合成含有甲基硫氨酸的环肽，在重编程的遗传密码下，涉及乙烯基甘氨酸的位点特异性结合，随后乙烯基甘氨酸异构化为脱氢丁氨酸，随后在乙烯基甘氨酸下游位置的分子内Michael添加半胱氨酸残基。
We report here the ribosomal synthesis of methyllanthionine-containing cyclic peptides involving a site-specific incorporation of vinylglycine under the reprogrammed genetic code, followed by the isomerization of the vinylglycine to dehydrobutyrine, and the subsequent intramolecular Michael addition of a cysteine residue placed at a downstream position of the vinylglycine.