Limited Effects of Low-to-Moderate Aerobic Exercise on the Gut Microbiota of Mice Subjected to a High-Fat Diet
Limited Effects of Low-to-Moderate Aerobic Exercise on the Gut Microbiota of Mice Subjected to a High-Fat Diet
复制标题
DOI：
10.3390/nu11010149
复制
发表时间：
2019-01-01
期刊：
影响因子：
5.9
通讯作者：
Petriz, Bernardo A.
中科院分区：
文献类型：
--
作者：
Ribeiro, Filipe M.;Ribeiro, Camila F. A.;Petriz, Bernardo A.
一些研究表明，饮食和锻炼可能会调节肥胖受试者的肠道微生物区系。这两种干预措施都能垂直改变微生物区系。然而，这种关系还没有得到充分的探索。本研究分析了低到中等有氧训练对高脂饮食(HFD)小鼠粪便微生物区系的影响。将40只雄性C57BL/6小鼠随机分为两组，分别给予标准饲料(SD；12.4%脂肪)和高脂饲料(60.3%脂肪)4个月。实验分为四组，分别为SD对照组、HF对照组、SD训练组和HF训练组。所有动物都接受了增量测试，以估计低到中等的最大速度。训练包括30min中心点日(-1)，5天/周，共8周。高脂饮食增加了体重(p<；0.0001)和肥胖指数(p<；0.05)。HFD对运动训练的表现也有负面影响。此外，HFD还降低了各组动物肠道微生物区系的多样性。低到中等的运动在调节HFD小鼠的肠道微生物区系组成方面无效。这些发现表明，在接受高脂肪饮食的情况下，两个月的低到中等强度的运动并不能对微生物群的形成产生明显的调节作用。
Several studies have indicated that diet and exercise may modulate the gut microbiota in obese subjects. Both interventions were shown to alter the microbiota orthogonally. However, this relationship has not been fully explored. This study analyzed the effects of low-to-moderate aerobic training on the fecal microbiota of mice subjected to a high-fat diet (HFD). Here, 40 male mice (C57Bl/6) were divided into two groups with standard diet (SD; 12.4% lipid) and HFD (60.3% lipid) for four months. These groups were divided into four, named SD control, HF control, SD trained and HF trained. All animals were submitted to an incremental test to estimate low-to-moderate maximum speed. Training consisted of 30 min center dot day(-1), 5 days/week, for 8 weeks. The HFD increased the body weight (p < 0.0001) and adiposity index (p < 0.05). HFD also negatively influenced performance in exercise training. Moreover, the diversity of gut microbiota was reduced by the HFD in all groups. A low-to-moderate exercise was ineffective in modulating the gut microbiota composition in mice subjected to HFD. These findings suggest that two months of low-to-moderate exercise does not achieve a preponderant modulatory effect on shaping microbiota when submitted to the high-fat diet.