Ovulation and risk of epithelial ovarian cancer
Ovulation and risk of epithelial ovarian cancer
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DOI：
10.1002/ijc.10927
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发表时间：
2003-03-20
影响因子：
6.4
通讯作者：
Green, AC
中科院分区：
文献类型：
--
作者：
Purdie, DM;Bain, CJ;Green, AC
排卵障碍被认为是上皮性卵巢癌的主要原因之一。然而，不同年龄的排卵和各种抑制排卵的暴露或事件的影响尚未确定。我们使用了来自澳大利亚的病例对照研究的数据，其中包括791例卵巢癌病例和853例对照，以检查排卵对卵巢癌风险的影响。使用每月避孕/生育日历中提供的信息以及其他信息（如平均月经周期长度）计算一生中的排卵总数。1年排卵期的增加与卵巢癌风险增加6%相关（95%置信区间[CI] = 4-8%）。20-29岁年龄组的排卵与最大的风险相关，在此年龄段内，每排卵一年，风险增加20%（95% CI = 13-26%）。当比较抑制排卵的不同暴露的影响时，有迹象表明某些因素可能比其他因素具有更大的影响。这些发现支持了这样一种理论，即持续排卵是卵巢癌发生的主要原因，并表明20多岁期间的排卵可能与疾病风险最相关。(C)2003 Wiley-Liss，Inc.
Incessant ovulation is thought to be one of the primary causes of epithelial ovarian cancer. However, the effects of ovulation at different ages and of the various exposures or events that suppress ovulation have not been established. We used data from an Australian case-control study of 791 ovarian cancer cases and 853 controls to examine the effect of ovulation on ovarian cancer risk. The total number of lifetime ovulations was calculated using information provided in a monthly contraceptive/reproductive calendar, as well as incorporating other information such as average menstrual cycle length. An increase of I year's worth of ovulation was associated with a 6% increase in risk of ovarian cancer (95% confidence interval [CI] = 4-8%). Ovulations in the 20-29-year age group were associated with the greatest risk, with a 20% increase in risk associated with each year of ovulation during this age period (95% Cl = 13-26%). When the effects of different exposures that suppress ovulation were compared, there was an indication that some factors may have a greater effect than others. These findings support the theory that incessant ovulation is a major contributor to the occurrence of ovarian cancer and suggest that ovulations during the 20s may be those most associated with disease risk. (C) 2003 Wiley-Liss, Inc.