Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
复制标题
DOI：
10.1126/science.1064890
复制
发表时间：
2001-11-16
期刊：
影响因子：
56.9
通讯作者：
Banchereau, J
中科院分区：
文献类型：
--
作者：
Blanco, P;Palucka, AK;Banchereau, J
树突状细胞（Dendritic cells，DC）在免疫和耐受调节中起重要作用。因此，我们假设系统性红斑狼疮（SLE），一种自身免疫性疾病的特点是自身反应性B和T细胞，可能是由于在DCs的功能改变。与此一致，发现来自SLE患者血液的单核细胞在体外起抗原呈递细胞的作用。SLE患者血清可诱导正常单核细胞分化为DC。这些DC可以从垂死的细胞中捕获抗原并将其呈递给CD 4阳性T细胞。SLE患者血清诱导DC分化的能力与疾病活动相关，并依赖于干扰素-α（IFN-α）的作用。因此，IFN-α对DCs的不减弱的诱导可能驱动SLE中的自身免疫应答。
Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-alpha (IFN-alpha). Thus, unabated induction of DCs by IFN-alpha may drive the autoimmune response in SLE.