Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates
Palladium-Catalyzed Monoarylation of Arylhydrazines with Aryl Tosylates
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DOI：
10.1021/acs.joc.0c01599
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发表时间：
2020-11-20
影响因子：
3.6
通讯作者：
Kwong, Fuk Yee
中科院分区：
文献类型：
--
作者：
Huang, Yange;Choy, Pui Ying;Kwong, Fuk Yee
采用钯催化芳基肼与芳基甲酰酸酯之间的C-N键偶联反应，制备了不对称N，N-二芳基肼。采用Pd(TFA)(2)与新开发的膦配体L1相结合的催化剂体系，芳酰肼的单芳基化反应顺利进行，以良好的收率（高达95%）获得所需的产物，具有良好的官能团相容性。该方法为从简单易得的偶联组分中获得结构多样化的N，N-二芳基肼提供了另一种合成途径。
A palladium-catalyzed C-N bond coupling reaction between arylhydrazines and aryl tosylates for facile synthesis of unsymmetrical N,N-diarylhydrazines has been developed. Employing the catalyst system of Pd(TFA)(2) associated with newly developed phosphine ligand L1, the monoarylation of arylhydrazine proceeds smoothly to afford desired products in good-to-excellent yields (up to 95%) with good functional group compatibility. This method provides an alternative synthetic pathway for accessing structurally diversified N,N-diarylhydrazines from simple and easily accessible coupling components.