EVIDENCE FOR A GENETIC ETIOLOGY IN READING-DISABILITY OF TWINS
EVIDENCE FOR A GENETIC ETIOLOGY IN READING-DISABILITY OF TWINS
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DOI：
10.1038/329537a0
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发表时间：
1987-10-08
期刊：
影响因子：
64.8
通讯作者：
LABUDA, MC
中科院分区：
文献类型：
--
作者：
DEFRIES, JC;FULKER, DW;LABUDA, MC
阅读障碍（难语症）是一个主要的社会、教育和心理健康问题。尽管对患病率的估计各不相同，但高达10-15%的学龄儿童尽管具有平均智力和充分的教育机会，但仍有严重的阅读缺陷。人们早就认识到阅读障碍可能与体质有关，对双胞胎和家庭的研究结果表明，阅读障碍的一种或多种形式可能是遗传的。然而，尚无遗传病因的确切证据。建立阅读障碍的遗传基础可以提出可能的原因，改进风险评估，促进早期诊断，并为表面上的亚型提供有效性测试。在这篇报告中，我们应用了最近开发的多元回归分析，对64对同卵双胞胎和55对异卵双胞胎的样本数据进行了分析，其中至少有一个成员是阅读障碍，并提供了一个重要的遗传病因的证据。
Reading disability (dyslexia) is a major social, educational, and mental health problem. Although estimates of prevalence vary, up to 10–15% of school-age children have severe reading deficits in spite of average intelligence and adequate educationalopportunity1. That reading disability may have aconstitutional basis has long been recognized2, and results of twin and family studies suggest that one or more of its forms may be heritable3,4; however, definitive evidence for a genetic aetiology has not been reported. Establishing a heritable basis for reading disability could suggestpossible causes, give improved risk estimates, facilitate early diagnosis, and provide validity tests for ostensible subtypes. In this report, we apply a recently developed multiple regression analysis5,6to data collected from a sample of 64 pairs of identical twins and 55 pairs of fraternal twins, in which at least one member of the pair is reading disabled, and present evidence for a significant genetic aetiology.