HUMAN ANTICENTRIOLE AUTOANTIBODY IN PATIENTS WITH SCLERODERMA AND RAYNAUDS-PHENOMENON
HUMAN ANTICENTRIOLE AUTOANTIBODY IN PATIENTS WITH SCLERODERMA AND RAYNAUDS-PHENOMENON
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DOI：
10.1016/0090-1229(83)90041-7
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
YOKOHARI, R
中科院分区：
文献类型：
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作者：
MOROI, Y;MURATA, I;YOKOHARI, R
通过间接免疫荧光法检测，在 2 名不同患者的血清中发现了独特的自身抗体，该抗体与培养的哺乳动物细胞和人外周白细胞的中心粒发生反应。来自同一个体（一个患有硬皮病，另一个患有雷诺现象）的血清也通过相同的技术对大鼠气管纤毛细胞的基体进行染色。随后研究的数据表明，参与反应的抗原是与中心粒相关的水不溶性蛋白质或多肽，与微管蛋白或嘌呤核苷磷酸化酶不同。
Unique autoantibody was found in sera from 2 different patients that reacted with centrioles of both cultured mammalian cells and human peripheral leukocytes as detected by the indirect immunofluorescent method. Sera from the same individuals, one with scleroderma and the other suffering from Raynaud''s phenomenon, also stained the basal bodies of rat tracheal ciliated cells by the identical technique. Data from subsequent investigations have suggested that the antigen(s) involved in the reaction are water-insoluble protein(s) or polypeptide(s) associated with centrioles and are distinct from microtubular proteins or purine nucleoside phosphorylase.