Determinants of quality of life in patients with cancer - A South American study
Determinants of quality of life in patients with cancer - A South American study
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DOI：
10.1002/cncr.20870
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发表时间：
2005-03-01
期刊：
影响因子：
6.2
通讯作者：
Hahn, EA
中科院分区：
文献类型：
--
作者：
Dapueto, JJ;Servente, L;Hahn, EA
背景由于健康相关的生活质量（QOL）是癌症管理的重要结果，作者试图更好地了解其决定因素。为了解决这个问题，他们分析了生活质量，测量与癌症治疗的功能评估-一般问卷（FACT-G），西班牙语版本4，并描绘了身体，心理，社会和文化因素之间的复杂关系，包括灵性。采用横断面研究设计，样本为309例癌症患者。首先通过单变量回归分析研究了几个可能的决定因素的影响。显示相关性的变量包括在向前逐步多变量回归模型中。研究了FACT-G总分及其四个分量表的五个回归模型。五个变量解释了FACT-G总评分的32.1%的方差：肿瘤分期、精神健康、收入、情绪障碍和问卷管理模式。解释变量的类型和相关性在QOL的各个维度之间存在差异。作者强调了生物学、心理社会学和精神因素作为癌症患者生活质量决定因素的交织，从而支持了该结构的多维定义和建模。(C)2005年美国癌症协会。
BACKGROUND. Because health-related quality of life (QOL) is an important outcome in cancer management, the authors sought to better understand its determinants. To address this subject, they analyzed QOL, as measured with the Functional Assessment of Cancer Therapy-General questionnaire (FACT-G), Spanish Version 4, and depicted the complex relations among physical, psychological, social, and Cultural factors, including spirituality.METHODS. A cross-sectional study design was used with a sample of 309 patients with cancer. The influence of several possible determinants was first studied by univariate regression analysis. Variables showing an association were included in a forward stepwise multivariate regression model.RESULTS. Five regression models were studied, for the FACT-G total score and its four subscales. Five variables explained 32.1% of the variance of the FACT-G total score: tumor stage, spiritual well-being, income, mood disorders, and mode of questionnaire administration. The type and relevance of the explanatory variables differed among the various dimensions of QOL.CONCLUSIONS. The authors underlined the entwining of biologic, psychosocial, and spiritual factors as determinants of the QOL of patients with cancer, thus Supporting the multidimensional definition and modeling of the construct. (C) 2005 American Cancer Society.