Preventive effects of an intergenerational program on age-related hippocampal atrophy in older adults: The REPRINTS study
Preventive effects of an intergenerational program on age-related hippocampal atrophy in older adults: The REPRINTS study
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DOI：
10.1002/gps.4785
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发表时间：
2018-02-01
影响因子：
4
通讯作者：
Fujiwara, Yoshinori
中科院分区：
文献类型：
--
作者：
Sakurai, Ryota;Ishii, Kenji;Fujiwara, Yoshinori
目标越来越多的文献表明，代际计划等社会参与是提高一系列认知能力的有效策略。本研究检验代际计划REPRINTS是否可以预防与年龄相关的海马萎缩。方法经过全面的基线评估后，让参与者决定是否参加REPRINTS干预或加入对照组，只需完成评估即可。 REPRINTS 参与者参与小组活动，其中包括为幼儿园和小学的孩子们阅读图画书，每 1 至 2 周一次。 6年后进行了跟踪评估。进行了两次 MRI 扫描，一次在基线评估后立即进行，另一次在 6 年后进行。海马体、丘脑和尾状核的体积来自自动分割。该分析包括 17 名 REPRINTS 和 42 名对照组参与者。结果 REPRINTS 组和对照组之间的参与者特征的任何变量在基线时没有显着差异。对照组的海马体积显着下降，但 REPRINTS 组的海马体积保持不变。未观察到各组之间丘脑或尾状核体积存在显着差异。尽管认知功能未受到该计划的影响，但海马体积的更大减少与认知表现得分的更大下降显着相关。结论我们的结果表明，REPRINTS 代际计划对老年人与年龄相关的海马萎缩具有保护作用。这些变化先于认知能力的改善，表明大脑可塑性概念在晚年社会参与后的有效性。
ObjectivesA growing body of literature indicates that social engagements, such as intergenerational programs, are effective strategies to improve a range of cognitive abilities. The present study examined whether the intergenerational programREPRINTSprevents age-related hippocampal atrophy.MethodsAfter comprehensive baseline assessment, participants were allowed to decide whether to participate in the REPRINTS intervention or in the control group, which required only completion of assessments. REPRINTS participants engaged in group activities that involved reading picture books to children at kindergarten and elementary schools, once every 1 to 2weeks. A follow-up assessment was conducted after 6years. Two MRI scans were performed, one immediately after baseline assessment and the other after 6years. Volumes of the hippocampus, thalamus, and caudate nucleus were derived from automated segmentation. The analysis included 17 REPRINTS and 42 control-group participants.ResultsThere was no significant difference in any variable of participants' characteristics at baseline between the REPRINTS and control groups. Hippocampal volume significantly declined in the control group but was maintained in the REPRINTS group. No significant differences between groups in thalamus or caudate nucleus volume were observed. Although cognitive function was unaffected by the program, greater decreases in hippocampal volume were significantly correlated with greater decreases in cognitive performance scores.ConclusionsOur results suggest that the REPRINTS intergenerational program has protective effects on age-related hippocampal atrophy in older adults. These changes precede improvements in cognitive performance, suggesting the validity of the concept of brain plasticity in later life following social engagement.