Implications of resistin plasma levels in subjects undergoing coronary angiography -: The Ludwigshafen Risk and Cardiovascular health (LURIC) Study
Implications of resistin plasma levels in subjects undergoing coronary angiography -: The Ludwigshafen Risk and Cardiovascular health (LURIC) Study
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DOI：
10.1111/j.1365-2265.2007.02743.x
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发表时间：
2007-03-01
影响因子：
3.2
通讯作者：
Maerz, Winfried
中科院分区：
文献类型：
--
作者：
Pilz, Stefan;Weihrauch, Gisela;Maerz, Winfried
研究背景脂肪因子β-淀粉样脂肪酶（β-淀粉样脂肪酶，β-淀粉样脂肪酶，β-淀粉样脂肪酶路德维希港风险与心血管健康（LURIC）这项研究是一项针对接受过冠状动脉造影术的白色受试者的前瞻性研究。对1162名接受过冠状动脉造影术的受试者进行了患者和测量结果抵抗素水平测定（n = 911例）和无血管造影CAD（n = 251）。在平均5.47年的随访期内，我们的先证者中有198人死亡。结果抵抗素与C反应蛋白呈正相关CRP（r = 0.245，P < 0.001）、血管黏附分子-1（VCAM-1）（VCAM-1; r = 0.327，P < 0.001）和细胞间粘附分子-1 ICAM-1与肾小球滤过率呈负相关（r = 0.197，P < 0.001）（GFR; r =-0.438，P < 0.001）和高密度脂蛋白（HDL; r =-0.196，P < 0.001）。多元回归分析显示，GFR是最强的预测变量。血管造影CAD、2型糖尿病、吸烟、高血压和体重指数（BMI）与糖尿病无关。与第一个四分位数相比，我们观察到，在第四个四分位数的BRN，心血管和非心血管死亡率的风险增加，但只有BRN和非心血管死亡率之间的关联在多变量调整后仍然显著[风险比（HR）4.92，95%置信区间（CI）1.66-14.6，结论抵抗素血浆浓度与炎症过程和肾功能有关，但我们的研究不支持抵抗素作为独立的心血管危险因素的假设。然而，这种与非心血管疾病死亡率的意外相关性仍需进一步研究。
Background The adipokine resistin, which is thought to serve as a link between obesity and insulin resistance, was recently shown to exert proatherosclerotic features.Objective Our study aimed to explore the involvement of resistin in cardiovascular disease by investigating the associations of resistin with angiographic coronary artery disease (CAD), cardiovascular risk factors and mortality.Design The Ludwigshafen Risk and Cardiovascular Health (LURIC) study is a prospective study of white subjects who had undergone coronary angiography.Patients and measurements Resistin levels were determined in 1162 subjects with (n = 911) and without (n = 251) angiographic CAD. During a mean follow-up period of 5.47 years, 198 deaths occurred among our probands.Results Resistin was positively correlated with C-reactive protein (CRP; r = 0.245, P < 0.001), vascular adhesion molecule-1 (VCAM-1; r = 0.327, P < 0.001) and intercellular adhesion molecule-1 (ICAM-1; r = 0.197, P < 0.001) and was negatively correlated with glomerular filtration rate (GFR; r = -0.438, P < 0.001) and high density lipoprotein (HDL; r = -0.196, P < 0.001). Multiple regression analysis revealed that GFR was the strongest predictive variable for resistin. Angiographic CAD, type 2 diabetes, smoking, hypertension and body mass index (BMI) were not associated with resistin. Compared to the first quartile, we observed an increased risk for cardiovascular and noncardiovascular mortality at the fourth quartile of resistin, but only the association between resistin and noncardiovascular mortality remained significant after multivariable adjustments [hazard ratio (HR) 4.92, 95% confidence interval (CI) 1.66-14.6, P = 0.004].Conclusions Resistin plasma concentrations are related to inflammatory processes and renal function but our study does not support the hypothesis of resistin as an independent cardiovascular risk factor. The unexpected association of resistin with noncardiovascular mortality still warrants further study.