Error processing -: evidence from intracerebral ERP recordings
Error processing -: evidence from intracerebral ERP recordings
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DOI：
10.1007/s00221-002-1201-y
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发表时间：
2002-10-01
影响因子：
2
通讯作者：
Rektor, I
中科院分区：
文献类型：
--
作者：
Brázdil, M;Roman, R;Rektor, I
在过去的十年中，几位作者描述了错误选择反应的头皮事件相关电位（ERP）中的早期负（Ne）和后期正（Pe）电位。本研究的目的是探讨这些电位的脑内起源和分布。7名难治性癫痫患者参加了这项研究。共231个网站在额叶，颞叶和顶叶进行了调查，通过深度电极。一个标准的视觉oddball范式进行，正确和不正确的运动反应的脑电图（EEG）时期的平均值独立。突出的，大多是双相，ERP复合物类似头皮Ne/Pe电位一致观察到在几个皮层位置后，不正确的试验。最一致的结果是从mesiotemporal结构，除了P3样活动后发现正确的反应，Ne/Pe复杂的检测后，一般不正确的试验。Pe的潜伏期比P3长。其他发电机的Ne/Pe样电位位于额叶的不同区域。Ne潜伏期顶叶最短，颞叶最长，额叶最长。我们的研究结果首次表明多个皮质结构产生Ne和Pe。除了头端前扣带皮层，近中颞叶和一些前额叶皮层似乎代表了大脑错误检查系统的组成部分。第二，Ne和Pe的配合物的耦合表明Ne和Pe的共同起源。第三，不同脑叶的Ne潜伏期差异表明Ne主要在后部和颞部被诱发，然后才在额叶被诱发。
Over the last decade, several authors have described an early negative (Ne) and a later positive (Pe) potential in scalp event-related potentials (ERPs) of incorrect choice reactions. The aim of the present study was to investigate the intracerebral origin and distribution of these potentials. Seven intractable epileptic patients participated in the study. A total of 231 sites in the frontal, temporal, and parietal lobes were investigated by means of depth electrodes. A standard visual oddball paradigm was performed, and electroencephalogram (EEG) epochs with correct and incorrect motor reactions were averaged independently. Prominent, mostly biphasic, ERP complexes resembling scalp Ne/Pe potentials were consistently observed in several cortical locations after incorrect trials. The most consistent findings were obtained from mesiotemporal structures; in addition to P3-like activity found after correct responses, an Ne/Pe complex was generally detected after incorrect trials. The Pe had a longer latency than the P3. Other generators of Ne/Pe-like potentials were located in different regions of the frontal lobe. The latency of the Ne was shortest in parietal, longer in temporal, and longest in frontal regions. Our findings firstly show that multiple cortical structures generate Ne and Pe. In addition to the rostral anterior cingulate cortex, the mesiotemporal and some prefrontal cortical sites seem to represent integral components of the brain's error-checking system. Secondly, the coupling of Ne and Pe to a complex suggests a common origin of Ne and Pe. Thirdly, the latency differences of the Ne across lobes suggest that the Ne is primarily elicited in posterior and temporal, and only later in frontal regions.