Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.
Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues.
复制标题
DOI：
--
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
G. Rice;J. Munro;Christopher L. Corless;M. Bevilacqua
中科院分区：
文献类型：
--
作者：
G. Rice;J. Munro;Christopher L. Corless;M. Bevilacqua
诱导型细胞粘附分子110（INCAM-110）是一种110 kd的淋巴细胞和单核细胞粘附受体，在精氨酸激活的内皮细胞上鉴定。使用免疫过氧化物酶技术，在正常人体组织的内皮上检测到很少或没有INCAM-110。相比之下，INCAM-110在各种活跃的炎症过程中在毛细血管后小静脉中表达。在急性阑尾炎中，发现INCAM-110与内皮白细胞粘附分子1（ELAM-1）的强表达一致，ELAM-1是一种在中性粒细胞粘附中起作用的精氨酸诱导分子。然而，在某些慢性炎症过程中（例如，结节病），观察到INCAM-110没有同时ELAM-1表达。抗INCAM-110抗体E1/6还标记了几种血管外细胞类型，包括淋巴树突状细胞、一些组织巨噬细胞、滑膜衬里细胞和反应性间皮细胞。这些数据表明内皮INCAM-110在急性和慢性炎症反应的病理生理学中的作用。此外，INCAM-110可作为单核白细胞在多种血管外部位的粘附分子。
Inducible cell adhesion molecule 110 (INCAM-110), is a 110-kd adhesion receptor for lymphocytes and monocytes identified on cytokine-activated endothelium. Using immunoperoxidase techniques, little or no INCAM-110 was detected on endothelium in normal human tissues. In contrast, INCAM-110 was expressed in postcapillary venules in a variety of active inflammatory processes. In acute appendicitis, INCAM-110 was found coincident with strong expression of endothelial leukocyte adhesion molecule 1 (ELAM-1), a cytokine-inducible molecule that functions in neutrophil adhesion. However, in certain chronic inflammatory processes (eg, sarcoidosis), INCAM-110 was observed without simultaneous ELAM-1 expression. Anti-INCAM-110 antibody E1/6 also marked several extravascular cell types, including lymphoid dendritic cells, some tissue macrophages, synovial lining cells, and reactive mesothelial cells. These data suggest a role for endothelial INCAM-110 in the pathophysiology of both acute and chronic inflammatory reactions. Furthermore INCAM-110 may function as an adhesion molecule for mononuclear leukocytes in a variety of extravascular sites.