Differential frontal activation in schizophrenia and bipolar illness during verbal fluency
Differential frontal activation in schizophrenia and bipolar illness during verbal fluency
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DOI：
10.1016/s0165-0327(00)00240-8
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发表时间：
2001-10-01
影响因子：
6.6
通讯作者：
McGuire, PK
中科院分区：
文献类型：
--
作者：
Curtis, VA;Dixon, TA;McGuire, PK
简介：精神分裂症额叶功能障碍的确切性质仍不清楚。我们之前已经使用功能磁共振成像证明了精神分裂症患者额叶激活的任务特异性减弱。通过在匹配的双相情感障碍受试者中使用相同的方法。我们试图确定这一发现是否是精神分裂症特有的，还是与一般精神病相关。方法：使用功能磁共振成像对五名右旋男性双相情感障碍患者以及精神分裂症受试者和对照组的匹配组进行研究。当受试者执行两项有节奏的任务时，获得回波平面图像：隐性言语流畅性和语义决策任务。通过正弦回归分析从单个图像构建通用大脑激活图。通过方差分析 (ANOVA) 在体素基础上确定实验响应平均功率的组间差异。结果：双相情感障碍患者在语言流利度过程中表现出广泛的前额叶激活，明显高于对照组。在语义决策任务期间，前额叶 BOLD 反应没有差异。结论：这些数据表明，与精神分裂症患者相比，双相情感障碍患者表现出显着不同的额叶反应模式，并提供了进一步的证据，表明精神障碍患者的异常额叶激活在语言流利性过程中比语义决策过程中更为明显。 (C) 2001 Elsevier Science B.V. 保留所有权利。
Introduction: The precise nature of frontal lobe dysfunction in schizophrenia remains unclear. We have previously demonstrated, using fMRI a task-specific attenuation of frontal activation in schizophrenic patients. By using an identical methodology in matched bipolar subjects. we sought to determine whether this finding is specific to schizophrenia or a correlate of psychosis in general. Method: Five dextral male bipolar patients and matching groups of schizophrenic subjects and controls were studied using fMRI. Echoplanar images were acquired while subjects performed two paced tasks: covert verbal fluency and a semantic decision task. Generic brain activation maps were constructed from individual images by sinusoidal regression analysis. Between-group differences in the mean power of experimental response were identified on a voxel-wise basis by an analysis of variance (ANOVA). Results: The bipolar patients showed extensive prefrontal activation during verbal fluency which was significantly greater than in controls. There was no difference in the prefrontal BOLD response during the semantic decision task, Conclusions: These data indicate that bipolar patients show a strikingly different pattern of frontal responses compared to those with schizophrenia and provide further evidence that abnormal frontal activation in psychotic disorders is more apparent during verbal fluency than semantic decision. (C) 2001 Elsevier Science B.V. All rights reserved.