Burden of premenstrual dysphoric disorder on health-related quality of life
Burden of premenstrual dysphoric disorder on health-related quality of life
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DOI：
10.1089/jwh.2007.0417
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发表时间：
2008-01-01
影响因子：
3.5
通讯作者：
Kornstein, Susan
中科院分区：
文献类型：
--
作者：
Yang, Min;Wallenstein, Gene;Kornstein, Susan
目的：本研究的目的是记录经前焦虑障碍（PMDD）对健康相关生活质量（HRQoL）的负担，并与美国的研究结果进行比较。S.方法：通过比较被确定为PMDD风险的妇女与在普通美国观察到的妇女之间的SF-12 v2（TM）评分，估计PMDD对HRQoL的疾病负担。S.女性人口。另外还对几种慢性健康状况进行了比较。使用回归方法估计一般人群样本的SF-12 v2标准值，并对其进行统计学调整，以匹配PMDD患者组的年龄和疾病合并症的存在。显著性检验用于比较样本间的平均值。结果：调整多重比较后，6个SF-12 v2量表和2个PMDD汇总指标均显著低于调整后的U。S.一般人口标准。PMDD的两个汇总指标的平均差异均大于低于正常值3分（临床有意义差异的阈值）。PMDD的负担是更大的精神/情感HRQoL领域比身体HRQoL。PMDD的HRQoL负担（1）在身体疼痛和精神健康（MH）量表中大于慢性背痛，在身体疼痛量表中大于2型糖尿病和高血压，而在三种疾病的所有其他量表中均相当，（2）在所有量表中与骨关节炎和类风湿性关节炎相当，（3）PMDD对HRQoL的生理和心理方面的负担较轻，而对其他量表的负担相当。
Objective: The purpose of this study was to document the burden of premenstrual dysphoric disorder (PMDD) on health-related quality of life (HRQoL) in comparison to the U. S. general population and specific chronic health conditions.Methods: The disease burden that PMDD placed on HRQoL was estimated by comparing SF-12v2 (TM) scores between women who were identified as being at risk for PMDD with those observed in the general U. S. female population. Additional comparisons were made to several chronic health conditions. Regression methods were used to estimate SF-12v2 normative values from the general population sample and statistically adjust them to match age and the presence of disease comorbidity of the PMDD patient group. Significance tests were used to compare the means across samples.Results: After adjusting for multiple comparisons, six SF-12v2 scales and two summary measures of PMDD were significantly below the adjusted U. S. general population norms. Both summary measures of PMDD had mean differences greater than 3 points below the norm ( threshold for clinical meaningful difference). The burden of PMDD was greater on mental/emotional HRQoL domains than on physical HRQoL. The HRQoL burden of PMDD was (1) greater than that of chronic back pain in bodily pain and mental health (MH) scales and greater than type 2 diabetes and hypertension in bodily pain scale while comparable in all other scales of the three conditions, (2) comparable to osteoarthritis and rheumatoid arthritis in all scales, and (3) less burden than depression in vitality and MH scales and mental component summary measure while comparable in other scales.Conclusions: PMDD is associated with substantial burden on both physical and mental aspects of HRQoL.