Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control
Monitoring drug efficacy and early detection of drug resistance in human soil-transmitted nematodes: a pressing public health agenda for helminth control
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DOI：
10.1016/j.ijpara.2004.08.001
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发表时间：
2004-10-01
影响因子：
4
通讯作者：
Savioli, L
中科院分区：
文献类型：
--
作者：
Albonico, M;Engels, D;Savioli, L
控制土壤传播的蠕虫感染和通过定期化疗消除淋巴丝虫病增加了对单剂驱虫药可能产生耐药性的药物压力。在兽医实践中，对封闭种群的频繁治疗导致了对驱虫剂耐药性的严重问题，现在这种耐药性在很大程度上是不可逆转的。单剂药物对人类线虫的药效下降应作为早期警告，适时解决这一问题。迫切需要研究和开发用于监测和早期检测耐药性的敏感工具，以维持迄今取得的蠕虫控制方案的好处。与国际伙伴采取协调一致的行动并建立一个科学家网络来解决这一问题，是控制蠕虫的下一个紧迫的公共卫生问题。(C)2004年澳大利亚寄生虫学协会，Elsevier Ltd.出版。版权所有。
Control of soil-transmitted helminth infection and elimination of lymphatic filariasis by periodic chemotherapy increase drug pressure for possible occurrence of resistance against single dose anthelminthics. In veterinary practice, frequent treatment of closed populations has led to a serious problem of anthelminthic drug resistance which is now largely irreversible. Reduced efficacy of single dose drugs against nematodes of humans should be taken as early warnings to tackle the issue in due time. Research and development of sensitive tools for monitoring and early detection of drug resistance is urgently needed to sustain the benefits of helminth control programs gained so far. A concerted action with international partners and the creation of a network of scientists to address this issue is the next pressing public health issue for helminth control. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.