Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide.
Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide.
复制标题
新生儿断奶时吸入一氧化氮时动脉氧张力的变化。
DOI：
10.1002/ppul.1083
复制
发表时间：
2001
影响因子：
3.1
通讯作者：
Ehrenkranz,RA
中科院分区：
文献类型：
--
作者：
Sokol,GM;Fineberg,NS;Wright,LL;Ehrenkranz,RA
我们开始评估当新生儿从吸入性一氧化氮（INO）中脱离时动脉血氧分压（PaO 2）的变化。我们回顾了505例前瞻性收集的84例缺氧性呼吸衰竭新生儿INO脱机尝试的记录。记录尝试脱机前和脱机后30 min的PaO 2值。使用回归分析和方差分析研究了PaO 2变化与INO浓度下降之间的关系。PaO 2下降（-18.7 ± 1.8托;P< 0.001）;当断奶INO时。从40 ppm开始，观察到PaO 2逐步下降。INO停药时下降幅度最大（-42.1 ± 4.1 Ω）。使用与PaO 2下降显著相关的变量进行的正向逐步多元回归分析表明，特定剂量减少7（P<0.001）、断奶前PaO 2（P< 0.001）和表面活性物质治疗（P= 0.018）是最能描述PaO 2变化的变量（P= 0.004，r = 0.51）。在停止使用之前，INO应降至低于1 ppm。先前的表面活性剂治疗似乎可以增强INO断奶时的氧合储备。小儿肺醇。2001; 32：14-19.© 2001 Wiley利斯公司
We set out to evaluate changes in arterial oxygen tension (PaO2) when weaning neonates from inhaled nitric oxide (INO). We reviewed the records of 505 prospectively collected INO weaning attempts on 84 neonates with hypoxic respiratory failure. PaO2values before and 30 min after weaning attempts were recorded. Relationships between change in PaO2and decreases in INO concentrations were investigated using regression analysis and ANOVA.PaO2decreased (−18.7 ± 1.8 torr;P< 0.001); when weaning INO. A stepwise decline in PaO2was observed weaning INO from 40 ppm. The greatest decline occurred when INO was discontinued (−42.1 ± 4.1 torr). Forward stepwise multiple regression using variables with significant relationships to the decline in PaO2identified the specific dose reduction 7(P< 0.001), the prewean PaO2(P< 0.001), and surfactant therapy (P= 0.018) as the variables best describing the change in PaO2(P= 0.004, r = 0.51).In conclusion, a graded decline in PaO2occurs when reducing INO. INO should be weaned to less than 1 ppm before discontinuing its use. Prior surfactant treatment appears to enhance the oxygenation reserve when weaning INO. Pediatr Pulmonol. 2001; 32:14–19. © 2001 Wiley‐Liss,Inc.