Helicobacter pylori infections and gastric cancer: The West African experience
Helicobacter pylori infections and gastric cancer: The West African experience
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幽门螺杆菌感染与胃癌：西非的经验
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
N. Awolola
中科院分区：
文献类型：
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作者：
F. Abdulkareem;K. Badmos;N. Awolola
在西非，幽门螺杆菌(Hp)的流行率很高，感染发生在儿童早期，但关于Hp与GC的关系的研究很少。尽管幽门螺杆菌的感染率很高，但胃癌的发病率很低，癌前病变也很少见。虽然大多数Hp菌株对毒力因子cagA基因以及VacA s1、m1或s1、m2都呈阳性，但与GC的关系并不一致。已有研究将胃癌的低发病率归因于CagA基因多个EPIYA-C片段株的低发生率以及cagA阳性株和cagA阴性株的混合感染，这可能是保护性的。研究还表明，富含抗氧化剂的饮食，如新鲜水果和蔬菜，可以降低胃癌的风险，而高盐饮食会增加CagA的高表达。因此需要更多的研究来解释西澳地区幽门螺杆菌感染的流行与胃癌之间的关系。
The prevalence of Helicobacter Pylori (Hp) in West Africa is high and infection occurs early in childhood but there are very few studies on association of Hp with GC. Despite the high prevalence of Hp, gastric cancer incidence is low and precancerous lesions are rare. Although most strains of Hp are positive for the virulent factor cagA gene as well as vacA s1, m1 or s1, m2; there is no consistent association with GC. Some studies have attributed the low incidence of GC to low prevalence of strains with multiple EPIYA-C segments of CagA gene and mixed infection by cagA positive and cagA negative strains which may be protective. Studies have also suggested that diets rich in anti-oxidants such as fresh fruits and vegetables decrease risk of GC while high salt diet increases the higher expression of CagA. More studies are therefore required to explain the dissociation between prevalence of Hp infection and gastric cancer in WA.