Morphological integration of the skull in craniofacial anomalies
Morphological integration of the skull in craniofacial anomalies
复制标题
DOI：
10.1111/j.1601-6343.2009.01448.x
复制
发表时间：
2009-08-01
影响因子：
3.1
通讯作者：
DeLeon, V. B.
中科院分区：
文献类型：
--
作者：
Richtsmeier, J. T.;DeLeon, V. B.
摘要作者：richsmier JT， DeLeon vj目的了解手术干预如何影响颅骨主要组成部分的组织和内部整合，我们解决围产期发育过程中功能和发育的关系。方法：形态学数据的量化模块化和整合方法有很多。在这里，从三维计算机断层扫描（CT）图像中得出的测量值被用来研究颅穹窿、面部和颅底测量值之间的统计关系。首先，我们在未受颅面异常影响的儿童样本中建立定量测量之间的关联模式。我们将这些规范的颅整合模式与面部异常（完全性单侧完全性唇裂和腭裂）和神经颅异常（孤立矢状缝闭）的儿童样本进行统计比较。最后，我们测试手术是否会影响受影响儿童颅底测量之间关联的强度和模式。结果：我们的分析显示，在未受影响的儿童和未手术的唇裂、腭裂和矢状缝闭的样本中，颅底有很强的内部整合。术后，颅面畸形患儿的颅底整合程度相对于术前有所降低。结论：我们的研究结果显示了颅底如何适应其更广泛的结构背景，并为颅底与颅穹窿和面部的发育和结构整合提供了额外的支持。
Structured AbstractAuthors -Richtsmeier JT, DeLeon VBObjectives -To understand how surgical interventions impact the organization and internal integration of the major components of the skull, we address the functional and developmental relationships during perinatal development.Methods -A number of methods for quantifying modularity and integration of morphological data are available. Here, measures derived from three-dimensional computed tomographic (CT) images are used to investigate the statistical relationships among measures of the cranial vault, face and cranial base. First, we establish the pattern of associations among quantitative measures in a sample of children unaffected by a craniofacial anomaly. We statistically compare these normative patterns of cranial integration to those of a sample of children with a facial anomaly (complete unilateral complete cleft lip and palate), and to children with a neurocranial anomaly (isolated sagittal synostosis). Finally, we test whether surgery affects the strength and pattern of associations among measures within the cranial base in the affected children.Results -Our analyses reveal strong internal integration of the cranial base in unaffected children and in our samples of unoperated cleft lip and palate, and sagittal synostosis. Post-operatively, the magnitude of integration of the cranial base is reduced relative to the pre-operative condition in both samples of children with craniofacial anomalies.Conclusion -Our results show how the cranial base adjusts to its broader structural context, and provides added support for the developmental and structural integration of cranial base with both cranial vault and face.