Hydrolysis of diethyl-p-nitrophenylphosphate and ethyl-p-nitrophenylethylphosphonate by human sera.
Hydrolysis of diethyl-p-nitrophenylphosphate and ethyl-p-nitrophenylethylphosphonate by human sera.
复制标题
人血清水解二乙基对硝基苯基磷酸酯和乙基对硝基苯基乙基磷酸酯。
DOI：
10.1016/0304-4165(68)90059-7
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发表时间：
1968
期刊：
影响因子：
--
通讯作者：
E. Reiner
中科院分区：
文献类型：
--
作者：
M. Škrinjarić;E. Reiner
It is known that organophosphorus compounds are hydrolysed by mammalian sera, but the specificity of the enzymes producing hydrolysis is rather complex and not yet fully understood. AUGUSTINSSON AND HEIMBORGER 1 have shown that tabun and DFP are hydrolysed by the same enzyme in rabbit plasma, while paraoxon, besides being split by this enzyme, is also split by another one, which in turn does not hydrolyse tabun and DFP 2. BEAKER AND BARBARO 3 have shown, that, in rabbit plasma, paraoxon is hydrolysed by a different enzyme than p-nitrophenyl-ethyl-npropylphosphonate and p-nitrophenyl-ethyl-n-pentylphosphonate. The enzyme hydrolysing paraoxon in rabbit, rat and horse serum was shown to be identical with an arylesterase 4. MAIN 5 has partially purified the enzyme hydrolysing paraoxon in sheep serum, and has shown that it hydrolyses tabun, but not tetraethylpyro-Abbreviations: Paraoxon, diethyl-p-nitrophenylphosphate; armine, ethyl-p-nitrophenylethylphosphonate; tabun, dimethylamido-ethoxy-phosphorylcyanide; DFP, diisopropyl-phosphorofluoridate.
