Diagnostic capacities and treatment practices on implantation mycoses: Results from the 2022 WHO global online survey.
Diagnostic capacities and treatment practices on implantation mycoses: Results from the 2022 WHO global online survey.
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植入植入物的诊断能力和治疗实践：2022年全球在线调查的结果。
DOI：
10.1371/journal.pntd.0011443
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发表时间：
2023-06
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
2022年1月至3月，世卫组织进行了一次全球在线调查，以收集不同环境下对四种植入性真菌病的诊断能力和治疗做法的数据：真丝酵母瘤、放线菌瘤、皮肤孢子丝菌病和嗜铬母细胞菌病。调查调查了各国在不同卫生系统级别(三级、二级、初级)可用的诊断方法类型和用于治疗植入性真菌病的药物，以期了解用于治疗这些疾病的药物再利用程度。来自包括各大洲在内的47个国家的142名受访者提供了数据：60%来自中等收入国家，59%在三级卫生系统工作，30%在二级卫生系统工作。本文提供的结果提供了关于药理学和非药理学干预的当前诊断能力和治疗趋势的信息。此外，这项调查提供了有关难治病例比率以及其他挑战的见解，例如药品的可获得性和可负担性，特别是在中等收入国家。尽管这项研究有局限性，但调查收集的数据证实，所有四种接受调查的植入性真菌病都发生了药物再利用。实施可公开查阅的植入性真菌病全球和/或国家治疗登记处，可有助于填补流行病学信息方面的空白，并收集有价值的观察数据，为治疗指南和临床研究提供信息。2022年6月，世界卫生组织(世卫组织)启动了皮肤相关被忽视热带病综合控制和管理框架。该框架描述了真菌瘤、嗜铬母细胞霉菌病和其他(深层)植入性真菌病，包括孢子丝菌病，应该如何在初级卫生保健环境中加以处理和整合。2022年1月至3月，世卫组织进行了一项全球在线调查，以收集有关世界各地用于治疗植入性真菌病的药物的信息。这项调查是世卫组织与美国食品和药物管理局合作项目的一部分，该项目旨在确定在CURE ID中进行试点测试的优先疾病领域，CURE ID是一个基于网络的应用程序，旨在帮助临床医生分享他们在管理难以治疗的传染病方面的经验，从而为支持药物再利用的临床研究需求提供信息。调查还探讨了不同卫生保健环境(三级、二级、初级)国家采用的诊断方法的类型以及用于治疗植入性真菌病的药物，以更好地了解诊断服务的做法和用于治疗这些疾病的药物重新用途的水平。
Between January and March 2022, WHO conducted a global online survey to collect data on diagnostic capacities and treatment practices in different settings for four implantation mycoses: eumycetoma, actinomycetoma, cutaneous sporotrichosis and chromoblastomycosis. The survey investigated the type of diagnostic methods available in countries at various health system levels (tertiary, secondary, primary level) and the medicines used to treat implantation mycoses, with a view to understanding the level of drug repurposing for treatment of these diseases. 142 respondents from 47 countries, including all continents, contributed data: 60% were from middle-income countries, with 59% working at the tertiary level of the health system and 30% at the secondary level. The results presented in this article provide information on the current diagnostic capacity and treatment trends for both pharmacological and non-pharmacological interventions. In addition, the survey provides insight on refractory case rates, as well as other challenges, such as availability and affordability of medicines, especially in middle-income countries. Although the study has limitations, the survey-collected data confirms that drug repurposing is occurring for all four surveyed implantation mycoses. The implementation of an openly accessible global and/or a national treatment registry for implantation mycoses could contribute to address the gaps in epidemiological information and collect valuable observational data to inform treatment guidelines and clinical research. In June 2022, the World Health Organization (WHO) launched a framework for integrated control and management of skin-related neglected tropical diseases. The framework describes how mycetoma, chromoblastomycosis and other (deep) implantation mycoses including sporotrichosis should be addressed and integrated in the primary health care settings. Between January and March 2022, WHO conducted a global online survey to collect information on the medicines used to treat implantation mycoses worldwide. The survey was designed as part of a WHO collaborative project with the United States Food and Drug Administration to identify priority disease areas for pilot testing in CURE ID, a web-based application to help clinicians share their experiences in managing difficult-to-treat infectious diseases and thereby inform clinical research needs to support drug repurposing. The survey also explored the type of diagnostic methods employed in countries within different health care settings (tertiary, secondary, primary level) and the medicines used to treat implantation mycoses, to obtain a better understanding of the practices in diagnostic services and level of drug repurposing for treatment of these diseases.
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