Targeting broadly neutralizing antibody precursors: a naïve approach to vaccine design.
Targeting broadly neutralizing antibody precursors: a naïve approach to vaccine design.
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针对广泛中和抗体前体：疫苗设计的一种简单方法。
DOI：
10.1097/coh.0000000000000548
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发表时间：
2019
影响因子：
4.1
通讯作者：
McGuire,AndrewT
中科院分区：
文献类型：
--
作者：
McGuire,AndrewT
生殖系靶向免疫原有望作为通过疫苗接种引发bNAb应答的第一步。一个更好的了解如何有效地生殖细胞靶向免疫原可以特异性靶向罕见的bNAb前体正在出现。此外，对bNAb诱导的关键障碍以及bNAb类别之间的共性的更全面的基于结构的理解可以进一步为疫苗设计提供信息。
Germline-targeting immunogens hold promise as a first step in eliciting a bNAb response through vaccination. A better understating of how efficiently germline-targeting immunogens can specifically target rare bNAb precursors is emerging. In addition, a more comprehensive structure-based understanding of critical barriers to bNAb elicitation, as well as commonalities between bNAb classes can further inform vaccine design.