HUMAN IMMUNOGLOBULIN-KAPPA LIGHT-CHAIN GENES ARE DELETED OR REARRANGED IN LAMBDA-PRODUCING B-CELLS
HUMAN IMMUNOGLOBULIN-KAPPA LIGHT-CHAIN GENES ARE DELETED OR REARRANGED IN LAMBDA-PRODUCING B-CELLS
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DOI：
10.1038/290368a0
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发表时间：
1981-01-01
期刊：
影响因子：
64.8
通讯作者：
LEDER, P
中科院分区：
文献类型：
--
作者：
HIETER, PA;KORSMEYER, SJ;LEDER, P
十个人类。检查产生轻链的B淋巴细胞。. kappa的基因在每一个中删除恒定区。只有20个可能的。卡帕。这些细胞中的等位基因被保留，甚至这种例外也被重排。.恒定区基因在每个8 κ中保持种系构型。检查产生轻链的人B淋巴细胞。以. kappa开始的轻链基因重排的层级。并继续进行.建议。
Ten human .lambda. light-chain-producing B lymphocytes were examined. Genes for the .kappa. constant region were deleted in each. Only 1 of the 20 possible .kappa. alleles in these cells was retained, and even this exception is rearranged. .lambda. constant region genes remain in the germ-line configuration in each of the 8 .kappa. light-chain-producing human B lymphocytes examined. A hierarchy of light-chain-gene rearrangement beginning with .kappa. and proceeding to .lambda. is suggested.