THE INTER-REGIONAL EPIDEMIOLOGICAL STUDY OF CHILDHOOD CANCER IRESCC CASE-CONTROL STUDY OF CHILDREN WITH CENTRAL NERVOUS SYSTEM TUMORS
THE INTER-REGIONAL EPIDEMIOLOGICAL STUDY OF CHILDHOOD CANCER IRESCC CASE-CONTROL STUDY OF CHILDREN WITH CENTRAL NERVOUS SYSTEM TUMORS
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DOI：
10.3109/02688699009000677
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发表时间：
1990-01-01
影响因子：
1.1
通讯作者：
ET AL
中科院分区：
文献类型：
--
作者：
BIRCH J M;HARTLEY A L;ET AL
中枢神经系统肿瘤占所有儿童癌症的 23%，是最常见的实体恶性肿瘤。人们对其病因知之甚少。本报告涉及对 78 例儿童中枢神经系统肿瘤病例进行的病例对照研究的结果。在以下方面没有发现病例对照差异：产前诊断X光、怀孕期间全身麻醉、怀孕感染、怀孕药物（包括镇静剂、镇定剂和抗惊厥药）、怀孕期间饮酒、儿童出生体重、母乳喂养、儿童疾病、儿童既往用药情况。大量病例母亲患有神经系统疾病（RR 2.6）。病例中已接种疫苗的儿童数量不足，已接近显着水平，而病例中先天性异常过多也已接近显着水平。病例父母中有少量患有肿瘤疾病。这项研究的结果表明，对于我们的患者来说，遗传因素比环境因素更重要，但本研究中纳入的人数较少意味着无法得出明确的结论。
Tumours of the central nervous system comprise 23% of all childhood cancers and form the most common group of solid malignancies. Little is know about their aetiology. The present report concerns the results of a case-control study of 78 incident cases of central nervous system tumours in children. No case-control differences were detected for the following: pre-natal diagnostic X-rays, general anaesthetics during pregnancy, pregnancy infections, pregnancy drugs (including sedatives, tranquillizers and anti-convulsants), alcohol consumption in pregnancy, child's birthweight, breast-feeding, childhood illnesses, previous medication in the child. A significant excess of case mothers had suffered from diseases of the nervous system (RR 2.6). There was a deficit of children who had been immunised among the case children which approached significance, and an excess of congenital abnormalities among cases which also approached significance. There was a small excess of neoplastic disease among case parents. The results of this study suggest that in our patients genetic rather than environmental factors are more important, but the small numbers included in the present study meant that no definite conclusions could be reached.