Antibody responses of variable lymphocyte receptors in the lamprey
Antibody responses of variable lymphocyte receptors in the lamprey
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DOI：
10.1038/ni1562
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发表时间：
2008-03-01
影响因子：
30.5
通讯作者：
Cooper, Max D.
中科院分区：
文献类型：
--
作者：
Alder, Matthew N.;Herrin, Brantley R.;Cooper, Max D.
七鳃鳗和八目鳗，无颌脊椎动物的活的代表，使用基因组富含亮氨酸的重复序列盒的组合组装的不同抗原受体基因编码可变的淋巴细胞受体的两种类型：VLRA和VLRB。我们在这里描述的VLRB轴承谱系的淋巴细胞在海七鳃鳗。这些细胞响应于细菌或哺乳动物细胞上的重复碳水化合物或蛋白质决定簇，具有淋巴母细胞样转化、增殖和分化成分泌多聚体抗原特异性VLRB抗体的浆细胞。七鳃鳗缺乏胸腺和对可溶性蛋白质抗原的反应能力，似乎已经进化出一种B细胞样系统来进行适应性体液反应。
Lamprey and hagfish, the living representatives of jawless vertebrates, use genomic leucine-rich-repeat cassettes for the combinatorial assembly of diverse antigen receptor genes encoding variable lymphocyte receptors of two types: VLRA and VLRB. We describe here the VLRB-bearing lineage of lymphocytes in sea lamprey. These cells responded to repetitive carbohydrate or protein determinants on bacteria or mammalian cells with lymphoblastoid transformation, proliferation and differentiation into plasmacytes that secreted multimeric antigen-specific VLRB antibodies. Lacking a thymus and the ability to respond to soluble protein antigens, lampreys seem to have evolved a B cell-like system for adaptive humoral responses.