Perceived Barriers to Pediatric Clinical Trials Implementation: A Survey of Health Care Staff.
Perceived Barriers to Pediatric Clinical Trials Implementation: A Survey of Health Care Staff.
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DOI：
10.17161/kjm.vol15.15885
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Davis, Ann M
中科院分区：
文献类型：
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作者：
Smith, Timothy R;McCulloh, Russell;Bui, Minh-Thuy;Sollo, Natalie;Ahlers-Schmidt, Carolyn R;Dedeaux, Julian A;Davis, Ann M
临床试验是评估治疗有效性和安全性的金标准。这项研究的目的是评估提供者对在堪萨斯州各地的不同实践环境中实施儿科临床试验的意见。这项研究是在向日葵儿科临床试验研究扩展中心(SPECTE)内完成的，该中心是IDEA国家儿科临床试验网络(ISPCTN)的一个附属机构。针对医疗保健提供者和诊所工作人员的全州便利性样本进行了一项横断面、包含36个项目的调查。共有115名卫生保健提供者和诊所工作人员完成了调查，其中31%是医生。医生比其他诊所工作人员更有可能拥有临床试验的经验(相关系数[CC]=0.270，p=0.004)。与城市受访者相比，农村医疗服务提供者在他们的业务中不太支持招募临床试验(CC=−0.251，p=0.008)，而更有可能愿意推荐患者进行涉及他们的保险不包括的治疗的临床试验(CC=0.302，p=0.001)。一系列农村和城市卫生保健专业人员支持进行儿科临床试验，但也发现了几个障碍。这些结果将支持包括堪萨斯州在内的全国范围内未来的儿科临床试验。
Clinical trials are the gold standard for assessing the effectiveness and safety of treatments. The objective of this study was to assess provider opinions regarding implementing pediatric clinical trials in various practice settings across Kansas. The study was completed within the Sunflower Pediatric Clinical Trials Research Extension (SPeCTRE), an affiliate of the IDeA States Pediatric Clinical Trials Network (ISPCTN). A cross-sectional, 36-item survey was administered to a state-wide convenience sample targeting health care providers and clinic staff. A total of 115 health care providers and clinic staff completed surveys; 31% were physicians. Physicians were more likely than other clinic staff to have experience with clinical trials (correlation coefficient [CC] = 0.270, p = 0.004). When compared to urban respondents, rural providers were less supportive of recruitment for clinical trials in their practices (CC = −0.251, p = 0.008) and more likely to feel comfortable referring patients for clinical trials involving treatments that their insurance did not cover (CC = 0.302, p = 0.001). A range of rural and urban health care professionals supported conducting pediatric clinical trials but identified several barriers as well. These results will support future pediatric clinical trials across the country including Kansas.