A Targeted Analysis of Serial Cytokine Measures and Nonpulmonary Organ System Failure in Children With Acute Respiratory Failure: Individual Measures and Trajectories Over Time.

A Targeted Analysis of Serial Cytokine Measures and Nonpulmonary Organ System Failure in Children With Acute Respiratory Failure: Individual Measures and Trajectories Over Time.
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急性呼吸衰竭儿童的系列细胞因子测量和非肺器官系统衰竭的针对性分析：个体测量和随时间变化的轨迹。

DOI：
10.1097/pcc.0000000000003286
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发表时间：
2023
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
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通讯作者：
BiomarkersinChildrenwithAcuteLungInjury(BALI)andRandomizedEvaluationforSedationTitrationforRespiratoryFail
BiomarkersinChildrenwithAcuteLungInjury(BALI)andRandomizedEvaluationforSedationTitrationforRespiratoryFail
中科院分区：
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文献类型：
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作者：
Ardila,SilviaM;Weeks,HeidiM;Dahmer,MaryK;Kaciroti,Niko;Quasney,Michael;Sapru,Anil;Curley,MarthaAQ;Flori,HeidiR;BiomarkersinChildrenwithAcuteLungInjury(BALI)andRandomizedEvaluationforSedationTitrationforRespiratoryFail

文献摘要

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结论：有必要进行研究，探索非肺器官功能障碍（NPOD）和生物标志物的时间趋势，以确定独特的预测或预后表型。在急性呼吸衰竭（ARF）的情况下，我们分别检测了NPODs的数量和轨迹与早期和晚期炎症级联反应激活的血浆生物标志物（特别是血浆白细胞介素-1受体拮抗剂（IL-1 ra）和白细胞介素-8（IL-8））之间的相关性。干预：NPODs针对血浆IL-1 ra和IL-8水平在个别天（插管后1至4天）和纵向跨越天进行评价。测量和主要结果：
OBJECTIVES:There is a need for research exploring the temporal trends of nonpulmonary organ dysfunction (NPOD) and biomarkers in order to identify unique predictive or prognostic phenotypes. We examined the associations between the number and trajectories of NPODs and plasma biomarkers of early and late inflammatory cascade activation, specifically plasma interleukin-1 receptor antagonist (IL-1ra) and interleukin-8 (IL-8), respectively, in the setting of acute respiratory failure (ARF).DESIGN:Secondary analysis of the Randomized Evaluation for Sedation Titration for Respiratory Failure clinical trial and Biomarkers in Acute Lung Injury (BALI) ancillary study.SETTING:Multicenter.PATIENTS:Intubated pediatric patients with ARF.INTERVENTIONS:NPODs were evaluated against plasma IL-1ra and IL-8 levels on individual days (1 to 4 d after intubation) and longitudinally across days.MEASUREMENTS AND MAIN RESULTS: